Frozen vs. claw: which biopsy tool wins for lung diagnosis?

NCT ID NCT05751278

Completed Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study from Johns Hopkins University compared two methods for taking lung tissue samples during a bronchoscopy: a 1.1mm cryoprobe (which freezes tissue) versus standard 2.0mm forceps (which grab tissue). The trial enrolled 500 adults scheduled for a lung biopsy and measured how often each tool led to a clear diagnosis, as well as bleeding complications. The goal was to see if the newer cryoprobe technique is more effective and safe than the traditional forceps approach.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If the cryoprobe proves better, it could become the new standard tool for lung biopsies, improving diagnosis for lung diseases.
What could go wrong: This is a completed device comparison study, so results are already known. The cryoprobe may not show a meaningful advantage over forceps, and any new tool carries risks like bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lung disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG DISEASES

Contacts and locations

Locations

Duke University Medical Center

Durham, North Carolina, 27710, United States
Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States
NYU Langone Health

New York, New York, 10016, United States
Northwestern Medicine

Chicago, Illinois, 60611, United States
The Medical University of South Carolina

Charleston, South Carolina, 29425, United States
University of Maryland, Baltimore (UMB)

Baltimore, Maryland, 21201, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
Vanderbilt University Medical Center (VUMC)

Nashville, Tennessee, 37232, United States
Washington University in Saint Louis (Wash-U)

St Louis, Missouri, 63130, United States

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