Frozen vs. claw: which biopsy tool wins for lung diagnosis?
NCT ID NCT05751278
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed study from Johns Hopkins University compared two methods for taking lung tissue samples during a bronchoscopy: a 1.1mm cryoprobe (which freezes tissue) versus standard 2.0mm forceps (which grab tissue). The trial enrolled 500 adults scheduled for a lung biopsy and measured how often each tool led to a clear diagnosis, as well as bleeding complications. The goal was to see if the newer cryoprobe technique is more effective and safe than the traditional forceps approach.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If the cryoprobe proves better, it could become the new standard tool for lung biopsies, improving diagnosis for lung diseases.
What could go wrong
This is a completed device comparison study, so results are already known. The cryoprobe may not show a meaningful advantage over forceps, and any new tool carries risks like bleeding.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Johns Hopkins Hospital
Baltimore, Maryland, 21287, United States
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NYU Langone Health
New York, New York, 10016, United States
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Northwestern Medicine
Chicago, Illinois, 60611, United States
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The Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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University of Maryland, Baltimore (UMB)
Baltimore, Maryland, 21201, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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Vanderbilt University Medical Center (VUMC)
Nashville, Tennessee, 37232, United States
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Washington University in Saint Louis (Wash-U)
St Louis, Missouri, 63130, United States