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Freezing out thyroid tumors: a new weapon in the fight?

NCT ID NCT07776262

Disease control Sponsor: Yukun Luo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This study tests whether freezing thyroid tumors with a probe (cryoablation) can safely shrink or eliminate them. It includes people with small papillary thyroid cancers and those with benign nodules. Researchers will track tumor size changes over a year and compare results with a microwave ablation group, while monitoring for side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ultrasound-guided percutaneous cryoablation (freezing) of thyroid tumors
What this could lead to
If freezing proves effective, it could offer a less invasive alternative to surgery for certain thyroid tumors, potentially reducing recovery time and risks.
What could go wrong
This is a relatively early study, and the outcome depends on tumor type and size. There is a risk of incomplete tumor destruction, nerve damage, or other side effects from the procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 108 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 【Group 1: Papillary Thyroid Carcinoma (PTC) patients】 1. Pre-operative ultrasound evaluation shows the maximum tumor diameter \<1 cm; 2. Papillary thyroid carcinoma (PTC) confirmed by ultrasound-guided fine-needle aspiration (FNA) biopsy; 3. Solitary PTC confirmed by pre-operative ultrasound; 4. Imaging examinations demonstrate no extrathyroidal invasion, cervical lymph node metastasis or distant metastasis. 【Group 2: Benign thyroid nodule patients】 1. Benign nodule confirmed by puncture biopsy; 2. Preoperative ultrasound confirms solid nodule with maximum diameter greater than 2 cm; 3. Patients refuse surgical treatment or cannot tolerate surgery, voluntarily receive thyroid ablation therapy and sign the informed consent form. Exclusion Criteria: 【Group 1: Papillary Thyroid Carcinoma (PTC) patients】 * (1) Biopsy confirms high-risk subtype papillary thyroid carcinoma; (2) History of thyroid surgery or radiotherapy; (3) Complicated with malignant tumors in other sites; (4) Severe coagulation dysfunction, or patients taking oral anticoagulants who have not reached the required drug-withdrawal period; (5) Incomplete follow-up data. 【Group 2: Benign thyroid nodule patients】 1. Patients with uncorrected psychiatric disorders or consciousness disturbance who cannot cooperate with treatment; 2. Patients with neck extension disorders of various causes who cannot cooperate with treatment; 3. Severe coagulation dysfunction, or patients taking oral anticoagulants who have not completed the required drug withdrawal period; 4. Severe cardiopulmonary insufficiency and inability to lie supine for the procedure; 5. Unrecovered recurrent laryngeal nerve injury contralateral to the lesion.

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Conditions

The condition(s) this trial relates to.

thyroid gland papillary carcinoma Thyroid Neoplasms thyroid tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Thyroid neoplasm Thyroid tumor

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Chinese People's Liberation Army General Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100853, China

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