New shingles vaccine CRV-101 takes on shingrix in Head-to-Head trial

NCT ID NCT05304351

Ongoing ⭐️ VACCINE ⭐️ Sponsor: Curevo Inc Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 study tests a new shingles vaccine called CRV-101 (amezosvatein) against the current standard, Shingrix, in about 1,500 adults aged 50 and older. The goal is to see if CRV-101 is safer and triggers a strong immune response. Participants receive two shots and are monitored for side effects and antibody levels over 14 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CRV-101 (amezosvatein) vaccine
What this could lead to: If successful, this could lead to a new shingles vaccine that is safer or as effective as Shingrix.
What could go wrong: This is an early phase 2 trial, so results may not confirm effectiveness. Side effects like injection site pain or fatigue are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chickenpox herpes zoster prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HERPES ZOSTER SHINGLES

Contacts and locations

Locations

Curevo Investigational Site

Tempe, Arizona, 85281, United States
Curevo Investigational Site

Coral Gables, Florida, 33134, United States
Curevo Investigational Site

Tampa, Florida, 33616, United States
Curevo Investigational Site

Oak Brook, Illinois, 60523, United States
Curevo Investigational Site

Lenexa, Kansas, 66219, United States
Curevo Investigational Site

Newton, Kansas, 67114, United States
Curevo Investigational Site

Lexington, Kentucky, 40509, United States
Curevo Investigational Site

Las Vegas, Nevada, 89119, United States
Curevo Investigational Site

Edmond, Oklahoma, 73013, United States
Curevo Investigational Site

Knoxville, Tennessee, 37909, United States
Curevo Investigational Site

Austin, Texas, 78745, United States
Curevo Investigational Site

Dallas, Texas, 75251, United States
Curevo Investigational Site

Euless, Texas, 76040, United States
Curevo Investigational Site

Salt Lake City, Utah, 84107, United States

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