New drug combo aims to shrink tough head and neck tumors

NCT ID NCT05249426

First seen Jan 29, 2026 · Last updated Jun 18, 2026 · Updated 23 times

Summary

This study tests a mix of antibodies that help the immune system fight cancer, block tumor growth signals, and cut off the tumor's blood supply. It is for adults with head and neck cancer that did not respond to prior treatment or has no standard options. Participants receive infusions every 1 to 3 weeks and are monitored for side effects and tumor shrinkage.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • "Prof. Dr. Alexandru Trestioreanu" Oncology Institut

    Bucharest, 022328, Romania

  • ARENSIA Exploratory Medicine

    Chisinau, MD-2025, Moldova

  • ARKE SMO S.A. de C.V

    Mexico City, 06700, Mexico

  • CTR Georges-François Leclerc

    Dijon, 21079, France

  • CTR Leon Berard

    Lyon, 69373, France

  • FAICIC S de RL de C.V.

    Veracruz, 91900, Mexico

  • HOP Civil

    Strasbourg, 67091, France

  • HOP Timone

    Marseille, 13385, France

  • Hammersmith Hospital

    London, W12 0HS, United Kingdom

  • Hospital Clínico San Carlos

    Madrid, 28040, Spain

  • Hospital Duran i Reynals

    L'Hospitalet de Llobregat, 08907, Spain

  • Hospital Sultan Ismail

    Johor Bahru, 81100, Malaysia

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • INS Claudius Regaud IUCT-Oncopole

    Toulouse, 31059, France

  • INS Curie

    Paris, 75248, France

  • Institute Of Oncology Prof. Dr. Ion Chiricuta Cluj-Napoca

    Cluj-Napoca, 400015, Romania

  • Investigacion Biomedica para el Desarrollo de Farmacos, S.A. de C.V.

    Zapopan, 45070, Mexico

  • Japanese Foundation for Cancer Research

    Tokyo, Koto-ku, 135-8550, Japan

  • King Chulalongkorn Memorial Hospital

    Bangkok, 10330, Thailand

  • King's College Hospital

    London, SE5 9RS, United Kingdom

  • Mandziuk Slawomir Specialist Medical Practice

    Lublin, 20-093, Poland

  • Sarawak General Hospital

    Kuching, Sarawak, 93586, Malaysia

  • Songklanagarind Hospital

    Songkhla, 90110, Thailand

  • The Royal Marsden Hospital, Chelsea

    London, SW3 6JJ, United Kingdom

  • Valkyrie Clinical Trials

    Los Angeles, California, 90067, United States

Conditions

The condition(s) this trial relates to.

head and neck squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.