New drug cocktail shows promise for tough head and neck cancers

NCT ID NCT05249426

First seen Jan 29, 2026 · Last updated Apr 28, 2026 · Updated 15 times

Summary

This study tests whether combining several drugs can shrink tumors in adults with head and neck cancer that has come back or spread. Participants receive up to three antibodies: two that help the immune system fight cancer, one that blocks tumor growth signals, and one that cuts off the tumor's blood supply. The trial is for people who have run out of standard treatments. Doctors monitor tumor size and side effects closely.

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Contacts and locations

Locations

  • "Prof. Dr. Alexandru Trestioreanu" Oncology Institut

    Bucharest, 022328, Romania

  • ARENSIA Exploratory Medicine

    Chisinau, MD-2025, Moldova

  • ARKE SMO S.A. de C.V

    Mexico City, 06700, Mexico

  • CTR Georges-François Leclerc

    Dijon, 21079, France

  • CTR Leon Berard

    Lyon, 69373, France

  • FAICIC S de RL de C.V.

    Veracruz, 91900, Mexico

  • HOP Civil

    Strasbourg, 67091, France

  • HOP Timone

    Marseille, 13385, France

  • Hammersmith Hospital

    London, W12 0HS, United Kingdom

  • Hospital Clínico San Carlos

    Madrid, 28040, Spain

  • Hospital Duran i Reynals

    L'Hospitalet de Llobregat, 08907, Spain

  • Hospital Sultan Ismail

    Johor Bahru, 81100, Malaysia

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • INS Claudius Regaud IUCT-Oncopole

    Toulouse, 31059, France

  • INS Curie

    Paris, 75248, France

  • Institute Of Oncology Prof. Dr. Ion Chiricuta Cluj-Napoca

    Cluj-Napoca, 400015, Romania

  • Investigacion Biomedica para el Desarrollo de Farmacos, S.A. de C.V.

    Zapopan, 45070, Mexico

  • Japanese Foundation for Cancer Research

    Tokyo, Koto-ku, 135-8550, Japan

  • King Chulalongkorn Memorial Hospital

    Bangkok, 10330, Thailand

  • King's College Hospital

    London, SE5 9RS, United Kingdom

  • Mandziuk Slawomir Specialist Medical Practice

    Lublin, 20-093, Poland

  • Sarawak General Hospital

    Kuching, Sarawak, 93586, Malaysia

  • Songklanagarind Hospital

    Songkhla, 90110, Thailand

  • The Royal Marsden Hospital, London

    London, SW3 6JJ, United Kingdom

  • Valkyrie Clinical Trials

    Los Angeles, California, 90067, United States

Conditions

Explore the condition pages connected to this study.