New drug combo aims to shrink tough head and neck tumors

NCT ID NCT05249426

Completed Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times

Summary

This study tests a mix of antibodies that help the immune system fight cancer, block tumor growth signals, and cut off the tumor's blood supply. It is for adults with head and neck cancer that did not respond to prior treatment or has no standard options. Participants receive infusions every 1 to 3 weeks and are monitored for side effects and tumor shrinkage.

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Conditions

The condition(s) this trial relates to.

head and neck squamous cell carcinoma hepatocellular carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD AND NECK SQUAMOUS CELL CARCINOMA (HNSCC)

Contacts and locations

Locations

"Prof. Dr. Alexandru Trestioreanu" Oncology Institut

Bucharest, 022328, Romania
ARENSIA Exploratory Medicine

Chisinau, MD-2025, Moldova
ARKE SMO S.A. de C.V

Mexico City, 06700, Mexico
CTR Georges-François Leclerc

Dijon, 21079, France
CTR Leon Berard

Lyon, 69373, France
FAICIC S de RL de C.V.

Veracruz, 91900, Mexico
HOP Civil

Strasbourg, 67091, France
HOP Timone

Marseille, 13385, France
Hammersmith Hospital

London, W12 0HS, United Kingdom
Hospital Clínico San Carlos

Madrid, 28040, Spain
Hospital Duran i Reynals

L'Hospitalet de Llobregat, 08907, Spain
Hospital Sultan Ismail

Johor Bahru, 81100, Malaysia
Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain
INS Claudius Regaud IUCT-Oncopole

Toulouse, 31059, France
INS Curie

Paris, 75248, France
Institute Of Oncology Prof. Dr. Ion Chiricuta Cluj-Napoca

Cluj-Napoca, 400015, Romania
Investigacion Biomedica para el Desarrollo de Farmacos, S.A. de C.V.

Zapopan, 45070, Mexico
Japanese Foundation for Cancer Research

Tokyo, Koto-ku, 135-8550, Japan
King Chulalongkorn Memorial Hospital

Bangkok, 10330, Thailand
King's College Hospital

London, SE5 9RS, United Kingdom
Mandziuk Slawomir Specialist Medical Practice

Lublin, 20-093, Poland
Sarawak General Hospital

Kuching, Sarawak, 93586, Malaysia
Songklanagarind Hospital

Songkhla, 90110, Thailand
The Royal Marsden Hospital, Chelsea

London, SW3 6JJ, United Kingdom
Valkyrie Clinical Trials

Los Angeles, California, 90067, United States

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