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New study aims to unravel mysterious brain vessel disease

NCT ID NCT05734404

Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 40 adults with central nervous system vasculitis (CNSV), a rare and serious inflammation of blood vessels in the brain that can cause strokes, memory loss, and other problems. Researchers will track participants' medical history, symptoms, and treatments to better understand how the disease develops and affects people over time. The goal is to gather knowledge that could improve future care, not to test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2023

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Individuals with central nervous system vasculitis (CNSV). Enrollment will be sequential and participants will have disease in various stages and of different duration.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: i. Diagnostic criteria for CNSV 1. The presence of an acquired and otherwise unexplained neurologic deficit 2. The presence of either classic angiographic or histopathologic features of angiitis in the CNS 3. No evidence of systemic vasculitis or any condition that could cause the angiographic or pathologic features ii. ≥18 years of age Exclusion Criteria: i. Unwilling to sign informed consent.

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Conditions

The condition(s) this trial relates to.

central nervous system vasculitis primary central nervous system vasculitis vasculitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Central nervous system vasculitis CNS vasculitis CNSV Vasculitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    6 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cleveland Clinic

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • St. Joseph's Healthcare

    RECRUITING

    Hamilton, Canada

  • University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • University of Toronto/Sinai Health

    RECRUITING

    Toronto, Canada

  • Vanderbilt University

    RECRUITING

    Nashville, Tennessee, 37232, United States

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