New study aims to match the right antipsychotic to the right patient
NCT ID NCT04580134
First seen Feb 06, 2026 · Last updated May 21, 2026 · Updated 16 times
Summary
This study tests whether clozapine, a powerful antipsychotic, works better than risperidone for people with schizophrenia, schizoaffective disorder, or bipolar 1 disorder who have a specific brain-based 'biotype.' About 320 adults will be randomly assigned to receive either clozapine or risperidone for 18 weeks. Researchers will measure changes in symptoms using a standard rating scale to see if clozapine leads to greater improvement in the targeted biotype group.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beth Israel Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02115, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hartford Healthcare
RECRUITINGHartford, Connecticut, 06106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UT Southwestern Medical Center
RECRUITINGDallas, Texas, 75235, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Chicago
RECRUITINGChicago, Illinois, 60615, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Georgia
RECRUITINGAthens, Georgia, 30602, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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