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Can the plastic in clear aligners change how much they hurt?

NCT ID NCT07790315

Symptom relief Sponsor: CMH Lahore Medical College and Institute of Dentistry Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time

Summary

Clear aligners straighten teeth with removable plastic trays, but different materials may cause different levels of pain and irritation. This trial compares two common plastics, TPU and PETG, to see which one patients find more comfortable. About 34 people with mild to moderate crowding will wear aligners made from one of the two materials for 10 days each. Researchers will track pain, mouth sores, tooth sensitivity, and other discomfort at several points during the first week.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Clear aligners made from either PETG or TPU thermoplastic material
What this could lead to
If one material proves more comfortable, it could guide orthodontists to choose aligners that cause less pain and mouth irritation for patients.
What could go wrong
This is a small, early-stage trial with only 34 participants, so results may not apply to everyone. Individual pain tolerance varies widely, and the study measures short-term discomfort over just one week.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 34 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 to 30 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • Patient aged between 15 and 30 years. * Permanent dentition, with all permanent teeth from first molar to first molar present. * Mild to moderate crowding less than 8 mm. * Non-extraction orthodontic treatment plan. * Ability and willingness to wear aligners for the required time. * Willingness to attend regular visits during orthodontic treatment. Exclusion Criteria: * • Syndromic patients. * Known allergy to thermoplastic materials. * Patients with systemic diseases that may affect orthodontic treatment or outcome assessment. * Patients requiring extraction as part of orthodontic treatment.

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Conditions

The condition(s) this trial relates to.

malocclusion due to protuberant upper front teeth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Malocclusion class II Malocclusion in children Malocclusion of anterior teeth

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CMH Lahore Medical college and institue of dentistry

    Lahore, Punjab Province, 54000, Pakistan

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