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Can a common amino acid help your body build more protein?

NCT ID NCT00756080

Knowledge-focused Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers are testing whether taking citrulline by mouth helps healthy adults build more protein throughout their bodies. Twelve healthy volunteers receive either citrulline or a placebo for seven days, then switch to the other. The study uses a safe tracer infusion to measure how the body handles protein, aiming to see if citrulline changes protein breakdown or synthesis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
citrulline, an amino acid supplement
What this could lead to
If citrulline helps healthy bodies build protein more efficiently, it could inform nutrition strategies for people who lose muscle, such as older adults or those recovering from illness.
What could go wrong
This is a Phase 1 study with only 12 healthy volunteers, so any effect seen may be small and may not apply to sick or older people. Citrulline is generally well tolerated, but the trial is too small to detect rare side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

12 people

The number who actually took part.

Start date

Sep 2008

Finished

Jan 2009

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy adult between 18 and 45 years of age * Absence of any earlier supplementation with citrulline, glutamine, ornithine a-ketoglutarate, or stimol® * Absence of any treatment with anabolic agents during the month prior to inclusion in the study- No current artificial feeding (enteral or parenteral) * No renal, cardiac, respiratory or hepatic insufficiency * No chronic inflammatory disease (intestinal or other * No current corticotherapy * Fasting blood glucose below 6mmol/L (126 mg/dL) * Body mass index between 19 and 24.9 * Patient able to understand benefits and risks of protocol * Not pregnant, taking oral contraceptive measure if able to procreate * Subject affiliated to French health insurance (Sécurité Sociale) * Informed consent form signed * No concomitant participation to another clinical trial, and compliance with the exclusion period required by law Exclusion Criteria: * Subject not fulfilling inclusion criteria * Subject mentioned in articles L1121-5 to L1121-8 of "code de la santé publique" * Subject for whom the participation in this clinical trial would result, by cumulating stipends received for other clinical trials, in earning more than 4500 € within 12 consecutive months

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy subjects

Contacts and locations

Locations

  • CHU Nantes

    Nantes, 44093, France

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