Can new techniques safely unblock the Heart's most stubborn clogs?

NCT ID NCT02061436

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time

Summary

This study gathers information from many hospitals on procedures used to open completely blocked coronary arteries—a condition called chronic total occlusion—in people with advanced heart disease. Researchers will track which techniques are used and how well they work, both right after the procedure and during follow-up. The goal is to better understand the safety and success of these procedures across different centers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Percutaneous coronary intervention (PCI) for chronic total occlusions
What this could lead to
If successful, this registry could reveal which techniques work best for opening fully blocked arteries, potentially improving outcomes for people with severe coronary artery disease.
What could go wrong
As a registry, it only observes and records what happens in real-world practice; it cannot prove which technique is best, and results may vary across centers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 2,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2012

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients undergoing CTO PCI at each of the participating centers.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients undergoing CTO PCI at each of the participating centers. Exclusion Criteria: * None

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    39 sites in 6 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Appleton Cardiology

    COMPLETED

    Appleton, Wisconsin, 54911, United States

  • Aswan Heart Centre

    RECRUITING

    Aswān, Egypt

  • Banner Samaritan Health Center

    COMPLETED

    Phoenix, Arizona, 85006, United States

  • Baylor Heart and Vascular Hospital

    RECRUITING

    Dallas, Texas, 75226, United States

  • Baylor Scott & White Research Institute-The Heart Hospital Baylor Plano

    RECRUITING

    Plano, Texas, 75093, United States

  • Baylor Scott and White Research Institute/ The Heart Hospital Baylor Plano

    RECRUITING

    Plano, Texas, 75093, United States

  • Beth Israel Deaconess Medical Center

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • Carolina East Medical Center

    RECRUITING

    New Bern, North Carolina, 28560, United States

  • Cleveland Clinic

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • Columbia University

    RECRUITING

    New York, New York, 10032, United States

  • Emory University Hospital- Emory Heart and Vascular Center

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Henry Ford Medical Center

    RECRUITING

    Detroit, Michigan, 48202, United States

  • Henry Hunant Hospital Center

    RECRUITING

    Athens, Greece

  • Houston Methodist Hospital

    ACTIVE_NOT_RECRUITING

    Houston, Texas, 77030, United States

  • Kettering Health Network

    RECRUITING

    Kettering, Ohio, 45429, United States

  • Korgialeneio-Benakeio Hellenic Red Cross General Hospital of Athens

    RECRUITING

    Athens, Attica, 11526, Greece

  • Little Rock VA Medical Center

    RECRUITING

    Little Rock, Arkansas, 72205, United States

  • Maimonides Medical Center

    RECRUITING

    Brooklyn, New York, 11219, United States

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

  • Medical Center of the Rockies

    RECRUITING

    Loveland, Colorado, 80538, United States

  • Memorial Hospital

    RECRUITING

    Jacksonville, Florida, 32216, United States

  • Meshalkin Novosibirsk Research Institute

    RECRUITING

    Novosibirsk, Novosibirsk Oblast, 630055, Russia

  • Mid America Heart Institute

    ACTIVE_NOT_RECRUITING

    Kansas City, Missouri, 64131, United States

  • Minneapolis Heart Institute

    RECRUITING

    Minneapolis, Minnesota, 55407, United States

  • Minneapolis VA Healthcare System and University of Minnesota

    RECRUITING

    Minneapolis, Minnesota, 55417, United States

  • Northwestern Bluhm Cardiovascular Institute

    ACTIVE_NOT_RECRUITING

    Chicago, Illinois, 60611, United States

  • Oklahoma City VA Medical Center

    RECRUITING

    Oklahoma City, Oklahoma, 73117, United States

  • Oklahoma Heart Institute at Hillcrest Medical Center

    RECRUITING

    Tulsa, Oklahoma, 74104, United States

  • Peacehealth Cardiology

    ACTIVE_NOT_RECRUITING

    Bellingham, Washington, 98225, United States

  • Piedmont Heart Institute

    ACTIVE_NOT_RECRUITING

    Atlanta, Georgia, 30309, United States

  • Providence Health Center

    ACTIVE_NOT_RECRUITING

    Waco, Texas, 76712, United States

  • Providence Heart & Vascular Institute

    RECRUITING

    Portland, Oregon, 97225, United States

  • San Diego VAMC and University of California

    RECRUITING

    San Diego, California, 92161, United States

  • St. Boniface General Hospital

    RECRUITING

    Winnipeg, Manitoba, R3E 0W3, Canada

  • St. George Hospital University Medical Center

    RECRUITING

    Beirut, Lebanon

  • St. Vincent Heart Center

    RECRUITING

    Indianapolis, Indiana, 46260, United States

  • The Christ Hospital Ohio Heart & Vascular

    RECRUITING

    Cincinnati, Ohio, 45219, United States

  • The Heart Hospital Baylor Plano

    RECRUITING

    Plano, Texas, 75093, United States

  • Torrance Memorial Medical Center

    ACTIVE_NOT_RECRUITING

    Torrance, California, 90505, United States

  • Trinity Medical WNY

    RECRUITING

    Buffalo, New York, 14221, United States

  • Tristar Centennial Medical Center

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • Tulane University Heart and Vascular Institute

    RECRUITING

    New Orleans, Louisiana, 70112, United States

  • University Hospitals (UH) Case Western Reserve University

    RECRUITING

    Cleveland, Ohio, 44106, United States

  • University of Pittsburgh Medical Center Presbyterian

    RECRUITING

    Pittsburgh, Pennsylvania, 15213, United States

  • University of Texas Southwestern Medical Center

    RECRUITING

    Dallas, Texas, 75216, United States

  • VA Dallas Medical Center

    RECRUITING

    Dallas, Texas, 75216, United States

  • WellSpan Heart & Vascular

    RECRUITING

    York, Pennsylvania, 17405, United States

  • Wellstar Health System

    RECRUITING

    Marietta, Georgia, 30060, United States

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