Can new techniques safely unblock the Heart's most stubborn clogs?
NCT ID NCT02061436
First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time
Summary
This study gathers information from many hospitals on procedures used to open completely blocked coronary arteries—a condition called chronic total occlusion—in people with advanced heart disease. Researchers will track which techniques are used and how well they work, both right after the procedure and during follow-up. The goal is to better understand the safety and success of these procedures across different centers.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Percutaneous coronary intervention (PCI) for chronic total occlusions
- What this could lead to
- If successful, this registry could reveal which techniques work best for opening fully blocked arteries, potentially improving outcomes for people with severe coronary artery disease.
- What could go wrong
- As a registry, it only observes and records what happens in real-world practice; it cannot prove which technique is best, and results may vary across centers.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 2,000 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2012
- Expected to finish
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Jan 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients undergoing CTO PCI at each of the participating centers.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients undergoing CTO PCI at each of the participating centers. Exclusion Criteria: * None
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
39 sites in 6 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Appleton Cardiology
COMPLETEDAppleton, Wisconsin, 54911, United States
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Aswan Heart Centre
RECRUITINGAswān, Egypt
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Banner Samaritan Health Center
COMPLETEDPhoenix, Arizona, 85006, United States
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Baylor Heart and Vascular Hospital
RECRUITINGDallas, Texas, 75226, United States
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Baylor Scott & White Research Institute-The Heart Hospital Baylor Plano
RECRUITINGPlano, Texas, 75093, United States
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Baylor Scott and White Research Institute/ The Heart Hospital Baylor Plano
RECRUITINGPlano, Texas, 75093, United States
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Beth Israel Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02215, United States
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Carolina East Medical Center
RECRUITINGNew Bern, North Carolina, 28560, United States
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
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Columbia University
RECRUITINGNew York, New York, 10032, United States
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Emory University Hospital- Emory Heart and Vascular Center
RECRUITINGAtlanta, Georgia, 30322, United States
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Henry Ford Medical Center
RECRUITINGDetroit, Michigan, 48202, United States
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Henry Hunant Hospital Center
RECRUITINGAthens, Greece
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Houston Methodist Hospital
ACTIVE_NOT_RECRUITINGHouston, Texas, 77030, United States
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Kettering Health Network
RECRUITINGKettering, Ohio, 45429, United States
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Korgialeneio-Benakeio Hellenic Red Cross General Hospital of Athens
RECRUITINGAthens, Attica, 11526, Greece
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Little Rock VA Medical Center
RECRUITINGLittle Rock, Arkansas, 72205, United States
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Maimonides Medical Center
RECRUITINGBrooklyn, New York, 11219, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Medical Center of the Rockies
RECRUITINGLoveland, Colorado, 80538, United States
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Memorial Hospital
RECRUITINGJacksonville, Florida, 32216, United States
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Meshalkin Novosibirsk Research Institute
RECRUITINGNovosibirsk, Novosibirsk Oblast, 630055, Russia
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Mid America Heart Institute
ACTIVE_NOT_RECRUITINGKansas City, Missouri, 64131, United States
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Minneapolis Heart Institute
RECRUITINGMinneapolis, Minnesota, 55407, United States
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Minneapolis VA Healthcare System and University of Minnesota
RECRUITINGMinneapolis, Minnesota, 55417, United States
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Northwestern Bluhm Cardiovascular Institute
ACTIVE_NOT_RECRUITINGChicago, Illinois, 60611, United States
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Oklahoma City VA Medical Center
RECRUITINGOklahoma City, Oklahoma, 73117, United States
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Oklahoma Heart Institute at Hillcrest Medical Center
RECRUITINGTulsa, Oklahoma, 74104, United States
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Peacehealth Cardiology
ACTIVE_NOT_RECRUITINGBellingham, Washington, 98225, United States
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Piedmont Heart Institute
ACTIVE_NOT_RECRUITINGAtlanta, Georgia, 30309, United States
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Providence Health Center
ACTIVE_NOT_RECRUITINGWaco, Texas, 76712, United States
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Providence Heart & Vascular Institute
RECRUITINGPortland, Oregon, 97225, United States
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San Diego VAMC and University of California
RECRUITINGSan Diego, California, 92161, United States
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St. Boniface General Hospital
RECRUITINGWinnipeg, Manitoba, R3E 0W3, Canada
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St. George Hospital University Medical Center
RECRUITINGBeirut, Lebanon
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St. Vincent Heart Center
RECRUITINGIndianapolis, Indiana, 46260, United States
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The Christ Hospital Ohio Heart & Vascular
RECRUITINGCincinnati, Ohio, 45219, United States
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The Heart Hospital Baylor Plano
RECRUITINGPlano, Texas, 75093, United States
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Torrance Memorial Medical Center
ACTIVE_NOT_RECRUITINGTorrance, California, 90505, United States
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Trinity Medical WNY
RECRUITINGBuffalo, New York, 14221, United States
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Tristar Centennial Medical Center
RECRUITINGNashville, Tennessee, 37203, United States
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Tulane University Heart and Vascular Institute
RECRUITINGNew Orleans, Louisiana, 70112, United States
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University Hospitals (UH) Case Western Reserve University
RECRUITINGCleveland, Ohio, 44106, United States
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University of Pittsburgh Medical Center Presbyterian
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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University of Texas Southwestern Medical Center
RECRUITINGDallas, Texas, 75216, United States
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VA Dallas Medical Center
RECRUITINGDallas, Texas, 75216, United States
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WellSpan Heart & Vascular
RECRUITINGYork, Pennsylvania, 17405, United States
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Wellstar Health System
RECRUITINGMarietta, Georgia, 30060, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Hospital-to-Home transitional cardiac rehabilitation as a transition from Centre-Based cardiac rehabilitation after cardiac surgery: a Single-Blind randomised controlled trial
- Opportunistic screening of coronary artery calcium on Non-Gated routine chest CT using artificial intelligence: retrospective external validation and clinical risk stratification
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