Can a 1950s antipsychotic help fight glioblastoma?
NCT ID NCT05190315
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-stage trial tested whether adding chlorpromazine, an old antipsychotic drug, to standard treatment (radiation and chemotherapy) is safe for people newly diagnosed with glioblastoma, an aggressive brain cancer. Ten adults took part. The main goal was to find a safe dose and check for side effects, not to measure if the drug works against the cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Chlorpromazine (Thorazine)
What this could lead to
If it works, this could point toward a new, affordable addition to standard therapy for glioblastoma, potentially improving outcomes.
What could go wrong
This is a very early, small phase 1 trial focused on safety, not effectiveness. The drug may not improve survival or could cause side effects.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Iowa Hospitals & Clinics
Iowa City, Iowa, 52242, United States