Could a Chemo-Free cocktail beat early breast cancer?
NCT ID NCT04733118
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether a combination of targeted cancer drugs (trastuzumab, pertuzumab, and T-DM1) can effectively treat HER2-positive early breast cancer without traditional chemotherapy. About 393 patients will receive these drugs as a subcutaneous injection, with surgery after treatment. The goal is to see if this approach can achieve a complete response and reduce the risk of recurrence while avoiding chemotherapy side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Trastuzumab, pertuzumab, and T-DM1 (targeted cancer drugs)
- What this could lead to
- If successful, this could offer a chemotherapy-free treatment option for some HER2-positive early breast cancer patients, potentially reducing harsh side effects while still controlling the disease.
- What could go wrong
- This is a phase 2 trial with no control group, so results are preliminary. The approach may not work for all patients, and targeted drugs still carry risks like heart or liver problems.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AO Ospedale Civile Legnano
Milan, Italy
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Azienda Ospedaliero Universitaria Di Bologna - Policlinico S.Orsola-Malpighi
Bologna, Italy
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Azienda Ospedaliero-Universitaria di Parma
Parma, Italy
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Békés county hospital
Békés, Hungary
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Centro Oncológico de Galicia
A Coruña, 15009, Spain
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Complejo Asistencial Universitario de León
León, Spain
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Complejo Hospitalario de Jaen
Jaén, Spain
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Consorcio Hospital General de Valencia
Valencia, Spain
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Consorcio Hospitalario Provincial De Castelló
Castellon, 12002, Spain
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Evangelisches Krankenhaus Bethesda
Duisburg, Germany
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Fondazione Policlinico Universitario Agostino Gemelli
Roma, Italy
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Hospital Arnau de Vilanova de Valencia
Valencia, Spain
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Hospital Clinico Universitario de Valencia
Valencia, Spain
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Hospital Clínico San Carlos
Madrid, 28040, Spain
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Hospital General Universitario de Alicante
Alicante, Spain
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Hospital La Fe
Valencia, 46026, Spain
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Hospital Quirón San Camilo- Ruber Juan Bravo
Madrid, Spain
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Hospital Ramón y Cajal
Madrid, Spain
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Hospital Universitari Arnau de Vilanova de Lleida
Lleida, Spain
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Hospital Universitari Dexeus - Grupo Quirónsalud
Barcelona, Spain
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Hospital Universitari San Joan de Reus
Reus, Tarragona, Spain
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Hospital Universitario A Coruña
A Coruña, Spain
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Hospital Universitario Clínico San Cecilio de Granada
Granada, Spain
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Hospital Universitario Reina Sofia
Córdoba, Cordoba, 14004, Spain
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Hospital Universitario Virgen del Rocio
Seville, Spain
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Hospital Universitario de Basurto
Bilbao, 48013, Spain
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Hospital Universitario de Torrejón
Torrejón, Spain
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ICO L'Hospitalet - Instituto Catalán de Oncología
L'Hospitalet de Llobregat, Barcelona, 08007, Spain
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Institut Català d' Oncologia Badalona (ICO)
Badalona, Spain
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Instituto Valenciano de Oncología (IVO)
Valencia, 46009, Spain
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Istituto Europeo di Oncologia - NC
Milan, Italy
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Kliniken Essen Mitte
Essen, Germany
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Klinikum Ernst von Bergmann
Potsdam, Germany
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Ospedale Guglielmo da Saliceto
Piacenza, Italy
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Ospedale San Gerardo
Monza, Italy
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Praxisnetzwerk Hämatologie und intern. Onkologie
Cologne, Germany
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Tolna County Balassa János Hospital
Szekszárd, Hungary
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UMHAT Sveti Ivan Rilski EAD Department of Medical Oncology
Sofia, Bulgaria
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Universitätsklinikum Essen Frauenklinik
Essen, Germany
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Universitätsklinikum Mannheim GmbH
Manheim, Germany
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VHIO Vall d'Hebron Institute of Oncology
Barcelona, Spain
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Young breast cancer patients share views on fertility risks in new survey
- New PET scan may tell doctors if chemo wiped out breast cancer without surgery
- Older women with Low-Risk breast cancer may avoid unnecessary surgery
- Could a pill replace chemo for some breast cancer patients?
- Scientists Re-Analyze old samples to unlock secrets of HER2-Low breast cancer