Can a glucose sensor help stave off diabetes?
NCT ID NCT07832474
First seen Sep 22, 2026 · Last updated Sep 22, 2026
Summary
Researchers are testing whether daily use of a continuous glucose monitor, paired with personalized lifestyle coaching, helps people with prediabetes spend less time with high blood sugar. The trial enrolls about 330 adults with prediabetes and assigns them to either CGM-guided care or usual care for 12 months. The main question is whether the CGM group lowers the percentage of time their blood sugar stays above 140 mg/dL more than the usual-care group.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- continuous glucose monitoring plus lifestyle coaching
- What this could lead to
- If it works, CGM-guided coaching could become a practical way to help people with prediabetes lower their blood sugar and reduce their risk of developing type 2 diabetes.
- What could go wrong
- This is a behavioral study, not a drug trial, so results depend on whether people stick with daily CGM use and lifestyle changes for a full year. Blood sugar improvements may fade once the study ends, and the findings may not apply to everyone with prediabetes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 330 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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May 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Provision of signed and dated informed consent form 2. \> 18 years of age 3. Documented diagnosis of prediabetes based on the most recent A1c of 5.7% to 6.4% (inclusive) collected within the last 12 months; or with investigator approval based on a history of A1c 5.7% to 6.4% (inclusive) 4. Point-of-care A1c between 5.7% and 6.4% (inclusive) at screening visit 5. A minimum of 7 days of glucose data with documented % time above 140 mg/dL of \> 15% on a study-provided blinded CGM during the baseline assessment period 6. Ready and able to make lifestyle changes to prevent or delay the onset of T2D; this may include changes to food intake, physical activity, sleep, and stress (e.g. ready to: make dietary changes, willing to aim for \> 150 mins of physical activity/week, etc.) 7. Has a personal smartphone that is compatible with all study-required devices and apps (e.g. FreeStyle Libre family, Fitbit) 8. Willing to download study-related apps and keep them updated and open on phone as required throughout the study (e.g. FreeStyle Libre family) 9. Has regular access to Wi-Fi 10. Willing and able to consistently view and use CGM data on a personal smartphone for up to 54 weeks 11. Willing and able to continuously wear a study provided CGM sensor (back of the arm) and a study provided Fitbit activity tracker (band around the wrist) for up to 54 weeks 12. Willing to attend in person and virtual study visits, willing to read MyChart messages, and willing to comply with all other study procedures and lifestyle considerations (Section 5.3, Lifestyle Considerations) for the duration of the study 13. Speak and read in English Exclusion Criteria: 1. Diagnosis of Type 1 diabetes or Type 2 diabetes (A1c \>6.4%) 2. Taking or actively planning to take anti-hyperglycemic medications (e.g. Metformin, SGLT2i, GLP-1 RA) 3. Taking or actively planning to take prescription weight loss medications (e.g. Phentermine, Topiramate, Naltrexone, Orlistat) 4. Taking or actively planning to take a GLP-1 RA for any reason 5. Known allergy to medical grade adhesive or isopropyl alcohol used to disinfect skin 6. Currently using or actively planning to use personal CGM, or have used personal CGM in last 30 days 7. Started taking within the last 16 weeks or actively planning to take a glucocorticoid (oral or injected), statin, thiazide diuretic, second-generation antipsychotic, or HIV medications, as these agents may increase the risk of developing T2D 8. Skin conditions that are not compatible with CGM wear 9. Taking or planning to regularly take more than 500 mg of Vitamin C per day (due to potential for false glucose elevations) 10. Planning pregnancy, pregnant, or lactating 11. Actively participating in or planning to participate in a treatment program for prediabetes (e.g. a diabetes prevention program) or a clinical intervention study related to cardiometabolic health 12. Unsuitable for participation due to any other cause, including but not limited to significant comorbidities, as determined by PI or MD oversight (e.g. examples for consideration, advanced cancer, unstable heart disease, active eating disorders, planned surgeries, cognitive impairments)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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HealthPartners
Bloomington, Minnesota, 55425, United States
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