Real-World data may reveal which breast cancer subtype responds best to CDK4/6 inhibitors

NCT ID NCT07704801

First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This study looks back at medical records of 300 people with metastatic luminal A or luminal B breast cancer who were treated with CDK4/6 inhibitors (Palbociclib, Ribociclib, or Abemaciclib). The goal is to see how long patients lived without their cancer getting worse, and whether the subtype of their cancer affected how well the drugs worked. By comparing real-world outcomes, researchers hope to learn which patients benefit most from these targeted therapies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
CDK4/6 inhibitors (Palbociclib, Ribociclib, or Abemaciclib)
What this could lead to
If successful, this study could help doctors choose the best CDK4/6 inhibitor for each breast cancer subtype, improving treatment personalization.
What could go wrong
This is a retrospective review of medical records, not a controlled trial, so results may be influenced by missing data or patient selection bias.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Sohag university hospital

    Sohag, Egypt

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