New immune cell therapy takes aim at Hard-to-Treat T-Cell cancers

NCT ID NCT03829540

Recruiting now Disease control Sponsor: Huda Salman Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial is testing a new type of immune therapy called CD4CAR for people with T-cell lymphoma or leukemia that has come back or not responded to treatment. The therapy uses a patient's own immune cells, which are modified in a lab to recognize and attack cancer cells that carry a protein called CD4. The main goal is to see if the treatment is safe and feasible in a small group of 20 participants.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CD4CAR T-cells (immune cells engineered to target CD4 on cancer cells)
What this could lead to: If it works, this could point toward a new treatment option for people with T-cell cancers that have not responded to standard therapy.
What could go wrong: This is a very early (Phase 1) and small (20 people) trial focused on safety, not effectiveness. The treatment may not work or could cause serious side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

leukemia lymphoma T-cell leukemia T-cell non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

T-CELL LEUKEMIA T-CELL LYMPHOMA

Contacts and locations

Locations

Albert Einstein Health Network
RECRUITING

New York, New York, 10467, United States
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
RECRUITING

Indianapolis, Indiana, 46202, United States
Riley Hospital for Children
RECRUITING

Indianapolis, Indiana, 46202, United States
Stony Brook Cancer Center
ACTIVE_NOT_RECRUITING

Stony Brook, New York, 11794, United States
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University of Miami Sylvester Comprehensive Cancer Center
RECRUITING

Miami, Florida, 33136, United States

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