Engineered immune cells take on tough leukemia in kids
NCT ID NCT06709469
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-stage trial is testing a type of immunotherapy called CAR T cells in children, adolescents, and young adults with acute lymphoblastic leukemia that has come back or not responded to standard treatments. The therapy involves taking the patient's own immune cells or donor cells, engineering them to better recognize and attack leukemia cells, and infusing them back. The main goal is to see if this approach is safe and feasible, with only 10 participants enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CAR T cells (immune cells engineered to target cancer)
- What this could lead to
- If successful, this could offer a new treatment option for young patients with leukemia that has not responded to standard therapies.
- What could go wrong
- This is a very early phase 1 trial with only 10 participants, so safety and feasibility are the main goals. The treatment may cause serious side effects like cytokine release syndrome, and it is not yet known if it will effectively control the disease long-term.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hospital Universitario La Paz
RECRUITINGMadrid, Madrid, 28046, Spain
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can donor immune cells be engineered to fight blood cancer?
- Can a Chemo-Antibody combo beat a tough leukemia?
- Personalized chemo dosing may boost leukemia remission in kids
- Personalized chemo dosing may boost survival in kids with High-Risk leukemia
- Targeted drug aims to clear hidden leukemia before transplant
- Supercharged immune cells take aim at cancer and viruses in one shot