New combo therapy aims to outsmart tough hodgkin lymphoma
NCT ID NCT04134325
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase pilot study is testing whether giving a PD-1 inhibitor (nivolumab or pembrolizumab) after CAR-T cell therapy can help people with relapsed or refractory classical Hodgkin lymphoma. The trial plans to enroll 10 adults whose cancer has not responded to at least three prior treatments. The goal is to see if the combination can shrink tumors and improve immune response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Nivolumab or Pembrolizumab (PD-1 inhibitors) after CD30-directed CAR-T cell therapy
- What this could lead to
- If successful, this approach could offer a new treatment option for patients with hard-to-treat Hodgkin lymphoma that has not responded to other therapies.
- What could go wrong
- This is a very early, small pilot study with only 10 participants. It may not show clear benefit, and results may not apply to all patients. Side effects from CAR-T and PD-1 inhibitors can be serious.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Lineberger Comprehensive Cancer Center at University of North Carolina
Chapel Hill, North Carolina, 27599, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- New combo aims to tackle tough lymphomas