New drug cocktail aims to stall breast cancer growth

NCT ID NCT04305496

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether adding capivasertib to standard fulvestrant therapy can slow cancer growth in people with advanced HR+/HER2- breast cancer. About 818 participants whose cancer worsened after hormone therapy will receive either the combination or a placebo plus fulvestrant. The main goal is to see how long the cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

capivasertib and fulvestrant

What this could lead to

If successful, this combination could offer a new treatment option to delay cancer progression for people with advanced HR+/HER2- breast cancer.

What could go wrong

This is a late-stage trial, but results are not yet final. The drug may not work for everyone and could cause side effects like diarrhea, rash, or high blood sugar.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

breast cancer hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED (INOPERABLE) OR METASTATIC BREAST CANCER

Contacts and locations

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Locations

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Gilbert, Arizona, 85234, United States
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Orange, California, 92868, United States
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San Francisco, California, 94143, United States
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Whittier, California, 90603, United States
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Fort Myers, Florida, 33905, United States
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Jacksonville, Florida, 32224, United States
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Westwood, Kansas, 66205, United States
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Baltimore, Maryland, 21201, United States
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Boston, Massachusetts, 02111-1520, United States
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Rochester, Minnesota, 55905, United States
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Kansas City, Missouri, 64132, United States
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St Louis, Missouri, 63156, United States
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Paramus, New Jersey, 07652, United States
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Farmington, New Mexico, 87401, United States
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Lake Success, New York, 11042, United States
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New York, New York, 10011, United States
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Greensboro, North Carolina, 27403, United States
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Chattanooga, Tennessee, 37404, United States
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Nashville, Tennessee, 37211, United States
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Dallas, Texas, 75246, United States
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Midlothian, Virginia, 23114, United States
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Puyallup, Washington, 98373, United States
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Berazategui, B1884BBF, Argentina
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Buenos Aires, C1125ABD, Argentina
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La Rioja, 5300, Argentina
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Rosario, S2000KZE, Argentina
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Viedma, R8500ACE, Argentina
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Adelaide, 5000, Australia
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Ballarat, 3350, Australia
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Birtinya, 4575, Australia
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Box Hill, 3128, Australia
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Concord, 2139, Australia
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Kurralta Park, 5037, Australia
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North Sydney, 2060, Australia
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Orange, 2800, Australia
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Ringwood East, 3135, Australia
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South Brisbane, 4101, Australia
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Waratah, 2298, Australia
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Wendouree, 3355, Australia
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Brussels, 1090, Belgium
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Brussels, 1200, Belgium
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Charleroi, 6000, Belgium
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Edegem, 2650, Belgium
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Namur, 5000, Belgium
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Wilrijk, 2610, Belgium
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Winnipeg, Manitoba, R3E 0V9, Canada
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Kingston, Ontario, K7L 2V7, Canada
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North York, Ontario, M2K 1E1, Canada
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Toronto, Ontario, M3M 0B2, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Baoding, 071000, China
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Beijing, 100044, China
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Beijing, 100191, China
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Changchun, 130021, China
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Chongqing, 400030, China
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Chongqing, 400042, China
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Dalian, 116011, China
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Foshan, 528000, China
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Gongshu District, 310022, China
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Guangzhou, 510080, China
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Guangzhou, 510095, China
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Hangzhou, 310003, China
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Hangzhou, 310020, China
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Harbin, 150081, China
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Hefei, 230001, China
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Hefei, 230022, China
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Jinan, 250001, China
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Linyi, 276001, China
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Nanchang, 330009, China
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Nantong, 226001, China
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Neijiang, 641000, China
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Shanghai, 200032, China
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Shanghai, 200127, China
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Shantou, 515031, China
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Shenyang, 110001, China
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Shenyang, 110042, China
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Wuhan, 430022, China
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Wuhan, 430030, China
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Wuhan, 430079, China
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Zhengzhou, 450008, China
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Besançon, 25000, France
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Brest, 29609, France
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Metz, 57085, France
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Pierre-Bénite, 69310, France
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Plerin SUR MER, 22190, France
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Pringy, 74374, France
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Rouen, 76038, France
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Strasbourg, 67065, France
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Toulouse, 31059, France
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Dresden, 01307, Germany
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Erlangen, 91054, Germany
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Essen, 45130, Germany
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Frankfurt, 60389, Germany
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Gelsenkirchen, 45879, Germany
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Hamburg, 20246, Germany
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Hamburg, 20249, Germany
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Hamburg, 20357, Germany
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Hanover, 30625, Germany
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Heidelberg, 69120, Germany
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Kiel, 24105, Germany
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Mannheim, 68167, Germany
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Minden, 32429, Germany
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München, 80637, Germany
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München, 81377, Germany
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Münster, 48149, Germany
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Paderborn, 33161, Germany
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Potsdam, 14467, Germany
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Budapest, 1122, Hungary
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Budapest, 1134, Hungary
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Debrecen, 4032, Hungary
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Kecskemét, 6000, Hungary
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Szekszárd, 7100, Hungary
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Szolnok, 5000, Hungary
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Afula, 1834111, Israel
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Beersheba, 84101, Israel
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Haifa, 31096, Israel
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Jerusalem, 91031, Israel
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Jerusalem, 91120, Israel
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Kfar Saba, 4428164, Israel
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Petah Tikva, 49100, Israel
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Ramat Gan, 52621, Israel
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Bergamo, 24127, Italy
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Candiolo, 10060, Italy
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Catanzaro, 88100, Italy
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Livorno, 57124, Italy
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Meldola, 47014, Italy
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Milan, 20141, Italy
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Modena, 41124, Italy
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Naples, 80131, Italy
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Prato, 59100, Italy
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Province of Macerata, 62100, Italy
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Roma, 00128, Italy
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Chiba, 260-8717, Japan
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Fukuoka, 811-1395, Japan
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Fukushima, 960-1295, Japan
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Hidaka-shi, 350-1298, Japan
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Hiroshima, 730-8518, Japan
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Kagoshima, 892-0833, Japan
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Kitaadachi-gun, 362-0806, Japan
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Kōtoku, 135-8550, Japan
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Kumamoto, 860-8556, Japan
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Kyoto, 606-8507, Japan
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Matsuyama, 791-0280, Japan
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Nagoya, 464-8681, Japan
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Nagoya, 467-8602, Japan
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Osaka, 540-0006, Japan
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Osaka, 541-8567, Japan
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Ota-shi, 373-8550, Japan
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Sapporo, 003-0804, Japan
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Sapporo, 060-8638, Japan
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Shinagawa-ku, 142-8666, Japan
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Tsu, 514-8507, Japan
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Yokohama, 241-8515, Japan
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Arequipa, AREQUIPA01, Peru
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Lima, LIMA 41, Peru
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Bydgoszcz, 85-796, Poland
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Krakow, 31-501, Poland
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Olsztyn, 10-228, Poland
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Warsaw, 02-781, Poland
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Moscow, 111123, Russia
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Moscow, 115478, Russia
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Saint Petersburg, 197758, Russia
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Saint Petersburg, 198255, Russia
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Samara, 443031, Russia
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Sochi, 354000, Russia
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Busan, 49241, South Korea
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Daegu, 41931, South Korea
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Goyang-si, 10408, South Korea
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Incheon, 22332, South Korea
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Seongnam-si, 13620, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 135-710, South Korea
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Seoul, 8308, South Korea
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Suwon, 16247, South Korea
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Suwon, 16499, South Korea
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A Coruña, 15009, Spain
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Barcelona, 08035, Spain
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Barcelona, 8003, Spain
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Córdoba, 14004, Spain
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Hosp de Llobregat(Barcelona), 08907, Spain
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Jaén, 23007, Spain
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La Laguna (Tenerife), 38320, Spain
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Lleida, 25198, Spain
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Madrid, 28007, Spain
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Madrid, 28033, Spain
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Madrid, 28034, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Madrid, 28046, Spain
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Majadahonda, 28222, Spain
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Málaga, 29010, Spain
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Pamplona, 31008, Spain
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Reus, 43204, Spain
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Santiago de Compostela, 15706, Spain
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Seville, 41013, Spain
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Valencia, 46009, Spain
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Valencia, 46010, Spain
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Kaohsiung City, 82445, Taiwan
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Taichung, 40447, Taiwan
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Tainan, 70403, Taiwan
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Tainan, 710, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 11217, Taiwan
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Taipei, 11259, Taiwan
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Taoyuan, 333, Taiwan
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Aberdeen, AB25 2ZN, United Kingdom
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Bournemouth, BH7 7DW, United Kingdom
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Bristol, BS2 8ED, United Kingdom
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Cardiff, CF14 2TL, United Kingdom
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Cheltenham, GL53 7AN, United Kingdom
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London, NW3 2QG, United Kingdom
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London, SW3 6JJ, United Kingdom
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Manchester, M20 4GJ, United Kingdom
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Sutton, SM25PT, United Kingdom