New drug duo tested in Tough-to-Treat cancers

NCT ID NCT05111561

Summary

This early-stage study is testing the safety and best dose of a new two-drug combination (ZEN003694 and binimetinib) for people with advanced solid tumors that have specific genetic changes in the RAS pathway, including triple-negative breast cancer. The trial aims to see if the drugs, taken as pills, can work together to stop cancer growth. The study is currently suspended and was designed to first find a safe dose and then see if the treatment shows any signs of helping control the cancer.

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Contacts and locations

Locations

  • Boston Medical Center

    Boston, Massachusetts, 02118, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

  • University of Texas Medical Branch

    Galveston, Texas, 77555-0565, United States

Conditions

Explore the condition pages connected to this study.