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Can a retinal photo reveal hidden heart risk?

NCT ID NCT07773064

Knowledge-focused Sponsor: Beijing Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 21, 2026 · Updated 2 times

Summary

This study is testing whether a combination of retinal eye scans and blood biomarkers can identify people at high risk for coronary artery disease (CAD). Researchers will use artificial intelligence to analyze detailed images of the blood vessels in the back of the eye, along with metabolic molecules in blood samples, to build a risk model. The study will follow 3,000 adults who are undergoing coronary angiography to see how well this model predicts future cardiovascular events. The goal is to develop a non-invasive screening tool that could improve early detection and management of heart disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple eye scan and blood test that helps doctors identify people at high risk for heart disease earlier, potentially preventing heart attacks.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The models may not be accurate enough for widespread use, and the results may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 3,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2024

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of inpatients recruited from Beijing Hospital, Beijing Haidian Hospital, and Beijing Friendship Hospital, Capital Medical University. Eligible participants are adults older than 18 years who provide informed consent and undergo coronary angiography during hospitalization because of symptoms suggestive of myocardial ischemia or the presence of multiple cardiovascular risk factors. This study builds upon and further expands an existing coronary artery disease (CAD) cohort based on retinal fundus imaging (ChiCTR2200066429), which began enrolling participants in June 2022.

Ages

18 to 100 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Older than 18 years * Symptoms suggestive of myocardial ischemia or the presence of multiple cardiovascular disease risk factors * Underwent coronary angiography during hospitalization * Underwent blood sample collection during hospitalization * Underwent bilateral color fundus photography during hospitalization * Availability of complete clinical data Exclusion Criteria: * History of heart transplantation or other solid-organ transplantation * Severe heart failure, defined as New York Heart Association (NYHA) functional class IV or left ventricular ejection fraction (LVEF) ≤20% * History of severe congenital heart disease, valvular heart disease, myocardial disease, pericardial disease, or aortic dissection * Pregnancy, breastfeeding, or plans to become pregnant during the study period * Progressive life-threatening disease * History of alcohol or drug abuse * Current treatment for a psychiatric disorder * Current receipt of radiotherapy or chemotherapy for a malignant tumor * Acute or chronic infectious disease * Severe hepatic insufficiency, renal insufficiency, thyroid disease and autoimmune disease * Life expectancy of less than 5 years * Ophthalmic diseases affecting the retinal vasculature or optic disc structure, including retinal artery occlusion, retinal vein occlusion, glaucoma, or congenital optic disc abnormalities * Color fundus photographs of insufficient quality because of severe ocular media opacity

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary artery disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Beijing Friendship Hospital, Capital Medical University

    NOT_YET_RECRUITING

    Beijing, Beijing Municipality, 100032, China

  • Beijing Haidian Hospital

    COMPLETED

    Beijing, Beijing Municipality, 100086, China

  • Beijing Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100730, China

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