Kidney cancer drug combo under the microscope in Real-World study

NCT ID NCT03647878

Ongoing Knowledge-focused Sponsor: Ipsen Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 5 times

Summary

This study observes 224 adults with advanced or metastatic kidney cancer who are taking cabozantinib alone or with nivolumab as their first treatment. Researchers track how often doses are reduced, paused, or stopped due to side effects in everyday medical practice. The goal is to understand real-world safety and dosing patterns, not to test new treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cabozantinib and nivolumab
What this could lead to: If successful, this study could help doctors better manage side effects and dosing for kidney cancer patients on these drugs.
What could go wrong: This is an observational study, not a treatment trial, so it won't test if the drugs work better than other options. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED RENAL CELL CARCINOMA METASTATIC RENAL CELL CARCINOMA

Contacts and locations

Locations

Asklepios Klinik Altona

Hamburg, Germany
Brüderkrankenhaus St. Josef Paderborn

Paderborn, 33098, Germany
Centrum für Operative Urologie

Bremen, 28277, Germany
Edia.med MVZ

Chemnitz, 09130, Germany
Elblandklinikum Riesa

Riesa, 01589, Germany
Evangelisches Krankenhaus Hamm gGmbH

Hamm, 59063, Germany
Facharztpraxis für Hämatologie und Internistische Onkologie

München, 80331, Germany
Fachzentrum für Urologie Eggenfelden

Eggenfelden, Germany
Franziskus Hospital Bielefeld

Bielefeld, 33615, Germany
GFO Kliniken Rhein-Berg

Bergisch Gladbach, Germany
GIM - Gemeinschaftspraxis Innere Medizin

Witten, 58455, Germany
Gemeinschaftspraxis

Garbsen, 30823, Germany
Gemeinschaftspraxis Hämatologie-Onkologie, Dresden

Dresden, Germany
Gemeinschaftspraxis für Urologie Cottbus

Cottbus, Germany
Hämatologisch-Onkologische Schwerpunktpraxis

Bad Liebenwerda, Germany
Immunologisch onkologisches MVZ

Hanover, 30449, Germany
Kepler Universitätsklinikum GmbH

Linz, 4021, Austria
Kliniken Maria Hilf GmbH

Mönchengladbach, 41063, Germany
Klinikum Bremen Mitte

Bremen, Germany
Klinikum Nürnberg

Nuremberg, 90419, Germany
Klinikum Osnabrück GmbH

Osnabrück, Germany
Klinikum Sindelfingen-Böblingen

Sindelfingen, 71065, Germany
Klinikum Solingen

Solingen, Germany
Klinikum Wels-Grieskirchen GmbH

Wels, 4600, Austria
Klinikum am Bruderwald Medizinische Klinik V

Bamberg, 96049, Germany
Krankenhaus Barmherzige Brüder Regensburg

Regensburg, Germany
Krankenhaus Martha-Maria Halle-Dölau

Halle, Germany
Krankenhaus Torgau J. Kentmann gGmbH

Torgau, Germany
Krankenhaus der Barmherzigen Brüder Trier

Trier, 54292, Germany
Kreiskliniken Herford

Herford, Germany
LMU Urologische Klinik und Poliklinik

München, Germany
Landeskrankenhaus Hochsteiermark

Leoben, A-8700, Austria
MVZ Kreis Olpe

Olpe, 57462, Germany
MVZ MP Saaletal

Saalfeld, 07318, Germany
MVZ Taunus GmbH

Bad Homburg, Germany
MVZ Urologie gGmbH

Nuremberg, Germany
Markuskrankenhaus

Frankfurt am Main, Germany
Medizinische Studiengesellschaft Nord-West GmbH

Westerstede, 26655, Germany
Onkologie am Segelfliegerdamm

Berlin, 12487, Germany
Onkologie aschaffenburg

Aschaffenburg, 63739, Germany
Onkologische Praxis Moers

Moers, 47441, Germany
Onkologische Schwerpunktpraxis

Kronach, Germany
Onkologisches Studienzentrum am Raschplatz

Hanover, 30161, Germany
Onkologisches Zentrum Donauwörth

Donauwörth, 86609, Germany
Onkozentrum Dresden/Freiberg

Dresden, 01127, Germany
Praxis Naunhof

Naunhof, Germany
Praxis Urologie Köpenick

Berlin, Germany
Praxis Urologie Köpenick

Zwickau, Germany
Praxis am Volkspark

Berlin, Germany
Praxis für Hämatologie und Internistische Onkologie

Neustadt am Rübenberge, 31535, Germany
Praxis für Hämatologie, Onkologie und Gerinnung

Kronach, 96317, Germany
Praxis für Urologie

Berlin, 12099, Germany
Praxis für Urologie, Andrologie, Onkologie und medikamentöse Tumortherapie

Markkleeberg, 04416, Germany
Praxisgemeinschaft für Onkologie und Urologie

Wilhelmshaven, 26389, Germany
Salzkammergutklinikum Vöcklabruck

Vöcklabruck, A-4840, Austria
Sana Klinikum Offenbach GmbH

Offenbach, Germany
St. Georg Klinikum

Eisenach, 99817, Germany
Studienzentrum UnterEms

Leer, Germany
Uniklinik Jena

Jena, Germany
Uniklinik Marburg

Marburg, Germany
Uniklinikum Erlangen

Erlangen, Germany
Uniklinikum Salzburg

Salzburg, A-5020, Austria
Universitätsklinikum Aachen

Aachen, Germany
Universitätsklinikum Augsburg A.ö.R

Augsburg, 86156, Germany
Universitätsklinikum Gießen und Marburg GmbH

Giessen, Germany
Universitätsklinikum Magdeburg

Magdeburg, 39120, Germany
Universitätsklinikum Münster

Münster, 48149, Germany
Universitätsmedizin Göttingen

Göttingen, 37075, Germany
Urologie

Potsdam, Germany
Urologische Arztpraxis

Bernburg, Germany
Urologische Arztpraxis

Eisleben Lutherstadt, 06295, Germany
Urologische Arztpraxis

Leipzig, Germany
Urologische Gemeinschaftspraxis

Dresden, 01307, Germany
Urologische Gemeinschaftspraxis

Neunkirchen, 66538, Germany
Urologische Praxis

Luckenwalde, Germany
Urologische Praxis

Parchim, 19370, Germany
Urologische Praxis Bad Schlema

Bad Schlema, Germany
Urologische Praxis Berlin

Berlin, Germany
Urologisches Zentrum Euregio

Aachen, Germany
Vivantes Klinikum am Urban

Berlin, Germany
Zentrum für Ambulante Onkologie

Schorndorf, 73614, Germany
Zentrum für urologische Onkologie, Palliativmedizin und allgemeine Urologie

Berlin, Germany

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