Real-World data shows promise for kidney cancer drug combo

NCT ID NCT05361434

Completed Disease control Sponsor: Ipsen Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study observed 311 adults with advanced kidney cancer who received cabozantinib (a targeted therapy) plus nivolumab (an immunotherapy) as their first treatment. Researchers tracked how long patients lived and how long tumors stayed under control in real-world settings. The goal was to see if the combination works as well outside clinical trials as it did in earlier studies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

cabozantinib and nivolumab

What this could lead to

If results are positive, this could confirm that the combination works well in everyday clinical settings, offering a standard first-line option for advanced kidney cancer.

What could go wrong

This is an observational study, not a controlled trial, so results may be less reliable. The combination also carries risks like fatigue, high blood pressure, and immune-related side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

clear cell renal carcinoma renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED RENAL CELL CARCINOMA

Contacts and locations

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Locations

AOU San Luigi Gonzaga

Orbassano, Italy
ATTIKO University Hospital

Chaïdári, Greece
Akershus Universitetssykehus

Lørenskog, Norway
Belfast City Hospital

Belfast, United Kingdom
CH Dentellières

Valenciennes, France
CHU Charles Nicolle

Rouen, France
CHU Namur Mont-Godinne

Yvoir, Belgium
CHU St Pierre & Brugmann

Brussels, Belgium
Centre Finisterien de Radiotherapie et d'Oncologie

Brest, France
Centre Georges François Leclerc

Dijon, France
Centre Hospitalier Annecy Genevois

Épagny, France
Centre Hospitalier Départemental Vendée

La Roche-sur-Yon, France
Centre Hospitalier Fleyriat

Bourg-en-Bresse, France
Centre Hospitalier Régional D'orléans

Orléans, France
Centre Hospitalier Régional Universitaire de (CHRU) de Tours - Hôpital Bretonneau

Tours, France
Centre Hospitalier Régional Universitaire de Besançon - Jean Minjoz

Besançon, France
Centre Hospitalier Tenon

Paris, France
Centre Hospitalier Universitaire (CHU) Henri Mondor

Créteil, France
Centre Hospitalier Universitaire (CHU) de Angers

Angers, France
Centre Hospitalier Universitaire (CHU) de Nantes - Hôtel-Dieu

Nantes, France
Centre Hospitalier Universitaire (CHU) de Poitiers

Poitiers, France
Centre Hospitalier Universitaire Grenoble Alpes

La Tronche, France
Centre Hospitalier Universitaire de Clermont-Ferrand - Gabriel-Montpied

Clermont-Ferrand, France
Centre Hospitalier de Boulogne-sur-mer

Boulogne-sur-Mer, France
Centre Hospitalier intercommunal Saint Raphaël Frejus

Fréjus, France
Centre d'Oncologie de l'Estuaire

Saint-Nazaire, France
Centre d'Urologie Site Médipole - Centre Catalan d'Urologie

Cabestany, France
Centre de Lutte Contre le Cancer Jean PERRIN

Clermont-Ferrand, France
Chonnam National University Hwasun Hospital

Jeongnam, South Korea
Clinique Mathilde Oncologie médicale

Rouen, France
Edinburgh Cancer Centre, Western General Hospital

Edinburgh, United Kingdom
Fondazione IRCCS, Istituto Nazionale dei Tumori

Milan, Italy
General Hospital of Athens Alexandra

Athens, Greece
Groupe Hospitalier De La Rochelle - Ré - Aunis

La Rochelle, France
Groupe Hospitalier Saint-André (Bordeaux)

Bordeaux, France
Henry Dunant Hospital

Athens, Greece
Hopital Bichat -Claud Bernard

Paris, France
Hopital Privé Jean Mermoz

Lyon, France
Hopital de Mercy- CHR Metz Thionville

Ars-Laquenexy, France
Hospital Foch - Oncology Service

Suresnes, France
Hospital Foch - Urology Service

Suresnes, France
Hôpital Européen Georges Pompidou (HEGP)

Paris, France
Hôpital Pitié-Salpétrière

Paris, France
Hôpital Privé Le Bois

Lille, France
ICANS - Institut de cancérologie Strasbourg Europe

Strasbourg, France
ICONE

Bezannes, France
IOV - Istituto Oncologico Veneto - IRCCS - Ospedale Busonera

Padova, Italy
Institut Bergonié

Bordeaux, France
Institut Ste Catherine - Institut du Cancer Avignon Provence

Avignon, France
Institut de Cancérologie de Bourgogne

Dijon, France
Institut de Cancérologie de Lorraine Alexis Vautrin

Vandœuvre-lès-Nancy, France
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"

Naples, Italy
Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori", IRCCS - Oncologia

Meldola, Italy
Jessa Ziekenhuis

Hasselt, Belgium
King Abdulaziz Medical City - Jeddah

Jeddah, Saudi Arabia
King Abdulaziz Medical City- Riyadh

Riyadh, Saudi Arabia
Ospedale "Santa Maria delle Croci" di Ravenna

Ravenna, Italy
Ospedale Generale Provincial

Province of Macerata, Italy
Ospedale San Camillo Forlanini

Roma, Italy
P.O Santa Maria delle Grazie, ASL Napoli 2 Nord

Pozzuoli, Italy
PU A.Gemelli, Università Cattolica del Sacro Cuore

Roma, Italy
Papageorgiou General Hosp of Thessaloniki

Thessaloniki, Greece
Policlinico Universitario Campus Biomedico

Roma, Italy
Samsung Medical Center

Seoul, South Korea
Seoul St Mary's Hospital

Seoul, South Korea
Severance Hospital, Yonsei University Health System

Seoul, South Korea