New drug cocktail shows promise for Hard-to-Treat cancers

NCT ID NCT02496208

First seen Nov 01, 2025 · Last updated May 12, 2026 · Updated 28 times

Summary

This early-phase study tests a combination of two or three drugs (cabozantinib, nivolumab, and sometimes ipilimumab) in people with advanced genitourinary cancers that have spread. The main goals are to find the safest doses and understand side effects. About 152 adults with various bladder, kidney, or penile cancers are taking part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • City of Hope Comprehensive Cancer Center

    Duarte, California, 91010, United States

  • Los Angeles General Medical Center

    Los Angeles, California, 90033, United States

  • NCI - Center for Cancer Research

    Bethesda, Maryland, 20892, United States

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • Rutgers Cancer Institute of New Jersey

    New Brunswick, New Jersey, 08903, United States

  • USC / Norris Comprehensive Cancer Center

    Los Angeles, California, 90033, United States

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

Conditions

Explore the condition pages connected to this study.

BLADDER SMALL CELL NEUROENDOCRINE CARCINOMA BLADDER SQUAMOUS CELL CARCINOMA BLADDER UROTHELIAL CARCINOMA CLEAR CELL RENAL CELL CARCINOMA INVASIVE BLADDER PLASMACYTOID UROTHELIAL CARCINOMA INVASIVE BLADDER SARCOMATOID UROTHELIAL CARCINOMA INVASIVE SARCOMATOID UROTHELIAL CARCINOMA KIDNEY MEDULLARY CARCINOMA MALIGNANT GENITOURINARY SYSTEM NEOPLASM MALIGNANT SOLID NEOPLASM PENILE CARCINOMA PENILE SQUAMOUS CELL CARCINOMA RENAL CELL CARCINOMA RENAL PELVIS UROTHELIAL CARCINOMA SARCOMATOID RENAL CELL CARCINOMA STAGE III BLADDER CANCER AJCC V8 STAGE III BLADDER CANCER AJCC V8 STAGE III PENILE CANCER AJCC V8 STAGE III PENILE CANCER AJCC V8 STAGE III PENILE CANCER AJCC V8 STAGE III RENAL CELL CANCER AJCC V8 STAGE III RENAL CELL CANCER AJCC V8 STAGE III RENAL CELL CANCER AJCC V8 STAGE III RENAL PELVIS AND URETER CANCER AJCC V8 STAGE III RENAL PELVIS AND URETER CANCER AJCC V8 STAGE III RENAL PELVIS AND URETER CANCER AJCC V8 STAGE III RENAL PELVIS CANCER AJCC V8 STAGE III RENAL PELVIS CANCER AJCC V8 STAGE III RENAL PELVIS CANCER AJCC V8 STAGE III URETER CANCER AJCC V8 STAGE III URETER CANCER AJCC V8 STAGE III URETER CANCER AJCC V8 STAGE III URETHRAL CANCER AJCC V8 STAGE III URETHRAL CANCER AJCC V8 STAGE III URETHRAL CANCER AJCC V8 STAGE IV BLADDER CANCER AJCC V8 STAGE IV PENILE CANCER AJCC V8 STAGE IV PENILE CANCER AJCC V8 STAGE IV RENAL CELL CANCER AJCC V8 STAGE IV RENAL CELL CANCER AJCC V8 STAGE IV RENAL PELVIS AND URETER CANCER AJCC V8 STAGE IV RENAL PELVIS AND URETER CANCER AJCC V8 STAGE IV URETER CANCER AJCC V8 STAGE IV URETER CANCER AJCC V8 STAGE IV URETHRAL CANCER AJCC V8 STAGE IV URETHRAL CANCER AJCC V8 URETER UROTHELIAL CARCINOMA URETER UROTHELIAL CARCINOMA URETHRAL UROTHELIAL CARCINOMA