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Which fix for clogged heart arteries works best when the heart is failing?

NCT ID NCT07817524

Disease control Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers compare two common procedures for people with severely blocked coronary arteries and a heart that pumps poorly. One group receives coronary artery bypass graft surgery, and the other receives percutaneous coronary intervention, also known as stenting. The study tracks deaths, heart attacks, and hospital readmissions to see which approach leads to better outcomes. About 300 adults with an ejection fraction of 35 percent or lower take part.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
coronary artery bypass graft surgery compared with percutaneous coronary intervention
What this could lead to
If one approach proves safer or more effective, doctors could have clearer guidance on which procedure to recommend for this high-risk group.
What could go wrong
Both procedures carry real risks in people with severely weakened hearts, and the study may not find a clear winner or may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All patients affected by coronary artery disease and severe left ventricular disfunction who underwent surgical treatment (coronary artery bypass grafting, CABG) or percutaneous treatment (percutaneous coronary intervention, PCI) between January 2019 and December 2023.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \>= 18 years old; * Written informed consent; * Indication to CABG surgery (both "on-pump" and "off-pump") or to PCI; * Preoperative EF ≤35%. Exclusion Criteria: * Inability to give written informed consent; * Emergency surgery; * Combined cardiac surgical procedures; * Previous cardiac surgery.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary artery disease Left ventricular cardiac dysfunction

Contacts and locations

Locations

  • Fondazione Policlinico Universitario A Gemelli IRCCS

    Roma, 00168, Italy

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