Can an extra inhaler boost lung clearance in cystic fibrosis patients already on breakthrough drugs?

This study looked at whether adding an inhaled medication called Bronchitol (mannitol) can further improve mucus clearance in people with cystic fibrosis who have moderate to severe lung disease and are already taking a triple-combination drug (elexacaftor/tezacaftor/ivacaftor). Fourteen adults participated, and researchers measured how quickly radioactive particles cleared from the lungs over one hour. The goal was to see if combining these treatments provides extra benefit beyond the modulator alone.