New hope for Hard-to-Treat lymphoma? drug targets cancer even when marker is low

NCT ID NCT02588651

First seen Nov 21, 2025 · Last updated Apr 28, 2026 · Updated 20 times

Summary

This study tested a drug called brentuximab vedotin in 23 people with a rare type of T-cell lymphoma that had stopped responding to or returned after prior chemotherapy. The drug is designed to seek out and kill cancer cells that have a specific marker called CD30, even when levels of that marker are very low. The main goal was to see how many patients' tumors shrank or disappeared after treatment.

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Contacts and locations

Locations

  • Cleveland Clinic Taussig Cancer institute, Case Comprehensive Cancer Center

    Cleveland, Ohio, 44195, United States

  • Hackensack University Medical Center

    Hackensack, New Jersey, 07601, United States

  • University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center

    Cleveland, Ohio, 44106, United States

  • Wayne State University, Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

Conditions

Explore the condition pages connected to this study.