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Brain Tumor's hidden chatter: scientists listen to single neurons during surgery

NCT ID NCT06617208

Knowledge-focused Sponsor: Erasmus Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Oct 05, 2026 · Last updated Oct 06, 2026 · Updated 1 time

Summary

Researchers at Erasmus Medical Center are testing whether they can record the activity of individual neurons in the brain tissue surrounding gliomas and other brain tumors during surgery. They use a tiny device called a Neuropixels probe, which is inserted into the peritumoral cortex to capture electrical signals from single neurons. The study aims to map how tumors change brain activity, which may contribute to epilepsy and tumor growth. The trial enrolls 20 adults with a suspected glioma or brain metastasis who are scheduled for surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Neuropixels probe recording
What this could lead to
If successful, this could help researchers understand how brain tumors disrupt nearby neurons and point toward new ways to treat tumor-related epilepsy and cognitive problems.
What could go wrong
This is a small, early-stage feasibility study with 20 participants. The recordings may not capture enough neurons to draw conclusions, and the approach may not translate into new treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \>18 yrs old with radiologically diagnosed brain tumor, suspect for glioma and/or metastasis. * Eligible for surgical resection or biopsy procedure according to standard practice. * Written Informed consent. * Able to undergo intra-operative neuromonitoring. Exclusion Criteria: * History of major psychiatric disorders (e.g., schizophrenia, bipolar disorder, or severe treatment-resistant depression) * Previous brain tumour surgery or radiotherapy. * Patient has pacemaker or other implanted electrical device such as vagal nerve stimulator or other. * Inability to give consent.

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Conditions

The condition(s) this trial relates to.

brain cancer brain glioma glioblastoma glioma metastatic malignant neoplasm in the brain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain metastasis Brain tumor-glioma Glioblastoma (GBM) GLIOMA

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Erasmus MC, Department of Neurosurgery

    RECRUITING

    Rotterdam, South Holland, 3015GD, Netherlands

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