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Brain scans aim to unlock mysteries of muscle disease

NCT ID NCT05854433

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This study looks at how myotonic dystrophy types 1 and 2 affect the brain. About 100 adults aged 30-65 will have MRI scans, thinking and movement tests, and blood draws. Some will also have a spinal tap. The goal is to find brain changes that could be used as markers in future treatment trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this study could identify brain imaging markers that help design better clinical trials for myotonic dystrophy treatments.
What could go wrong
This is an observational study, not testing a treatment. It may not lead directly to new therapies, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction muscular dystrophy myotonic dystrophy myotonic dystrophy type 1 myotonic dystrophy type 2 neurodegenerative disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYOTONIC DYSTROPHY TYPE 1 MYOTONIC DYSTROPHY TYPE 2

Contacts and locations

Locations

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157, United States

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