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Can targeted brain zaps ease Parkinson's tremors without drugs?

NCT ID NCT06980935

Symptom relief Sponsor: Ruijin Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 09, 2026 · Last updated Sep 10, 2026 · Updated 1 time

Summary

Researchers are testing whether a non-invasive brain stimulation technique called temporal interference stimulation can improve motor symptoms in people with early-to-mid-stage Parkinson's disease. The study compares stimulation while participants are on and off their usual Parkinson's medication to see if the stimulation works independently. Twenty participants receive individualized stimulation based on MRI scans and have their motor symptoms scored. The goal is to learn whether this approach could help control symptoms with or without medication.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
individualized 130 Hz subthalamic temporal interference stimulation, a non-invasive brain stimulation technique delivered by the NervioX-2400 device
What this could lead to
If it works, this could offer a drug-free way to ease Parkinson's motor symptoms, either alongside or instead of medication.
What could go wrong
This is a small, early study of 20 people, so results may not hold up in larger groups. Brain stimulation can cause scalp discomfort or headaches, and its effects may be temporary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Apr 2025

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * MDS diagnosis of primary Parkinson's disease * Hoehn \& Yahr stage \< 3 * Antiparkinsonian drugs remained unchanged in the past four weeks and dosage remained unchanged during the study Exclusion Criteria: * Presence of neurological disorders that may affect the study (e.g., Traumatic brain injury) * History of antipsychotics, antidepressants, or dopamine modulators other than PD drugs * Metal devices in the head or heart (e.g., deep brain stimulators, pacemakers) * Unstable vital signs

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson disease

Contacts and locations

Locations

  • Ruijin Hospital

    Shanghai, Shanghai Municipality, China

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