New trial tests best way to zap large brain tumors before surgery

NCT ID NCT07329634

Not yet recruiting Disease control Sponsor: Maciej Harat Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial will compare two radiation approaches for people with large brain metastases (tumors that spread from other cancers). One group gets a single high-dose radiation before surgery; the other gets five smaller doses of radiation alone. The goal is to see which method better prevents tumor regrowth, radiation-induced brain damage, or spread of cancer in the brain lining. About 98 adults with tumors 2.5 to 6 cm will take part across multiple Polish centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Stereotactic radiosurgery (pre-surgery or multi-fraction radiation)
What this could lead to: If successful, this could establish a better radiation approach for large brain metastases, reducing the chance of tumor regrowth or brain complications.
What could go wrong: This is a relatively small Phase 3 trial (98 participants) and results may not apply to all patients. Both radiation types carry risks like brain swelling or tissue damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer metastatic malignant neoplasm in the brain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN METASTASIS

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Other studies related to the condition(s) this trial covers.