New trial tests best way to zap large brain tumors before surgery
NCT ID NCT07329634
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial will compare two radiation approaches for people with large brain metastases (tumors that spread from other cancers). One group gets a single high-dose radiation before surgery; the other gets five smaller doses of radiation alone. The goal is to see which method better prevents tumor regrowth, radiation-induced brain damage, or spread of cancer in the brain lining. About 98 adults with tumors 2.5 to 6 cm will take part across multiple Polish centers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Stereotactic radiosurgery (pre-surgery or multi-fraction radiation)
What this could lead to
If successful, this could establish a better radiation approach for large brain metastases, reducing the chance of tumor regrowth or brain complications.
What could go wrong
This is a relatively small Phase 3 trial (98 participants) and results may not apply to all patients. Both radiation types carry risks like brain swelling or tissue damage.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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