Brain mets showdown: radiation plus new combo drug tested in lung cancer
NCT ID NCT07234877
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests two treatment plans for people with lung cancer that has spread to the brain but is not causing major symptoms. One group gets focused radiation to all brain tumors first, then a new immunotherapy drug (ivonescimab) plus chemotherapy. The other group gets the immunotherapy and chemo right away. The goal is to see which approach better delays brain tumor growth. About 158 adults will take part.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Academisch Ziekenhuis Maastricht
Maastricht, Netherlands
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Azienda Sanitaria Universitaria Friuli Centrale (Ospedaliero Universitario "Santa Maria della Misericordia" )
Udine, 33100, Italy
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Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
Brescia, Italy
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CLCC-Jean Perrin
Clermont-Ferrand, 63000, France
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Centre Antoine Lacassagne
Nice, 06189, France
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Centre Leon Berard
Lyon, 69373, France
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Diagnostic & Therapeutic Center of Athens Hygeia Hospital S.A.
Athens, 151 23, Greece
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Erasmuc Mc
Rotterdam, Netherlands
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General hospital of Athens 'Alexandra'
Athens, 11528, Greece
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Gustave Roussy
Villejuif, t 94805, France
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Hospital Universitari Son Espases
Palma de Mallorca, 07120, Spain
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Hospital Universitario 12 De Octubre
Madrid, 28041, Spain
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Hospital Universitario de La Princesa
Madrid, 28006, Spain
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Institut Godinot
Reims, 51056, France
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Kepler University Hospital
Linz, 4021, Austria
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Medical University of Vienna
Vienna, 1090, Austria
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Metropolitan Hospital
Athens, Greece
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Ospedale Fatebenefratelli Isola Tiberina Gemelli Isola
Roma, 00186, Italy
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Policlinico Universitario Campus Bio-Medico- Oncology Center
Roma, 00128, Italy
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RCCS Ospedale San Raffaele
Milan, Italy
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The Institute Of Oncology
Ljubljana, 1000, Slovenia
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UMC-Academisch Ziekenhuis Utrecht
Utrecht, Netherlands
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Univ. Rostock-Zentrum für Radiologie mit Klinik und Poliklinik für Strahlentherapi
Rostock, 18058, Germany
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Universitaetsklinikum Jena
Jena, 07447, Germany
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University Clinic Golnik
Golnik, 4204, Slovenia
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University Hospital Frankfurt -Senckenberg Institute of Neurooncology
Frankfurt am Main, 60590, Germany