New cell therapy takes on Hard-to-Treat cancers

NCT ID NCT05120271

First seen Jan 05, 2026 · Last updated May 15, 2026 · Updated 20 times

Summary

This early-phase study tests a new treatment called BOXR1030, which uses specially designed immune cells to target a protein (GPC3) found on certain advanced solid tumors. The study involves 7 adults with liver, lung, skin, or soft tissue cancers that have not responded to standard therapies. The main goals are to check safety and find the best dose, with participants receiving the cells after chemotherapy.

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Contacts and locations

Locations

  • Baylor Scott and White Research Institute

    Dallas, Texas, 75246, United States

  • Beatson Institute for Cancer Research Wolfson Wohl Cancer Research Centre

    Glasgow, G61 1BD, United Kingdom

  • Fred Hutchinson Cancer Center - Seattle Cancer Care Alliance (SCCA) Location

    Seattle, Washington, 98109, United States

  • Froedtert and Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Hoag Hospital Newport Beach

    Newport Beach, California, 92663, United States

  • The Royal Marsden NHS Foundation Trust

    London, SW3 6JJ, United Kingdom

  • University College London Hospitals NHS Foundation Trust

    London, NW1 2PG, United Kingdom

  • University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030-4008, United States

Conditions

Explore the condition pages connected to this study.