New pill could tame rare blood disorder without chemotherapy

NCT ID NCT06456346

Ongoing Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 3 times

Summary

This phase 3 trial compares bomedemstat, an experimental oral drug, to hydroxyurea (standard therapy) in 300 people with essential thrombocythemia who have not yet received cytoreductive treatment. The goal is to see if bomedemstat better controls platelet counts and prevents complications like blood clots or bleeding. Participants take capsules daily for at least a year, with regular monitoring.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bomedemstat (also called MK-3543)
What this could lead to: If bomedemstat works better than hydroxyurea, it could offer a new first-choice treatment to control platelet counts and reduce the risk of blood clots or bleeding in people with essential thrombocythemia.
What could go wrong: This is a phase 3 trial, so results are not yet known. Bomedemstat may not prove superior to hydroxyurea, and side effects could limit its use. The study is still recruiting, so findings are years away.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

essential thrombocythemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESSENTIAL THROMBOCYTHEMIA

Contacts and locations

Locations

Aarhus Universitetshospital, Skejby-Blodsygdomme ( Site 0324)

Aarhus, Central Jutland, 8200, Denmark
Akademiska sjukhuset ( Site 0545)

Uppsala, Uppsala County, 751 85, Sweden
Anhui Provincial Hospital ( Site 0657)

Hefei, Anhui, 230001, China
Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 0502)

Ankara, 06800, Turkey (Türkiye)
Ankara UTF Cebeci Arastırma ve Uygulama Hastanesi ( Site 0511)

Ankara, 6620, Turkey (Türkiye)
Antalya Egitim ve Arastırma Hastanesi ( Site 0508)

Antalya, 07100, Turkey (Türkiye)
Arthur J.E. Child Comprehensive Cancer Centre ( Site 0038)

Calgary, Alberta, T2N 5G2, Canada
Austin Health-Cancer Clinical Trials Centre ( Site 0206)

Heidelberg, Victoria, 3084, Australia
Azienda Ospedaliera Universitaria Careggi ( Site 0441)

Florence, Tuscany, 50134, Italy
Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo ( Site 0443)

Alessandria, 15121, Italy
Biocenter ( Site 0149)

Concepción, Biobio, 4070196, Chile
Boston Pilgrim Hospital ( Site 0525)

Boston, Lincolnshire, PE21 9QS, United Kingdom
Bradfordhill-Clinical Area ( Site 0142)

Santiago, Region M. de Santiago, 8420383, Chile
C.I.C.E. 9 de Julio ( Site 0104)

San Miguel de Tucumán, Tucumán Province, T4000IKO, Argentina
CHU Bordeaux Haut-Leveque-service de mèdecine interne et maladies infectieuses ( Site 0346)

Pessac, Aquitaine, 33600, France
Carmel Hospital ( Site 0426)

Haifa, 3436212, Israel
Centre Hospitalier Régional Universitaire de Tours - Hôpital-Hématologie et Thérapie Cellulaire ( Site 0342)

Tours, Indre-et-Loire, 37000, France
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren ( Site 0344)

Limoges, Haute-Vienne, 87042, France
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu ( Site 0347)

Nantes, Pays de la Loire Region, 44093, France
Centre Hospitalier Universitaire de Nice - Hôpital l'Archet-Hematology ( Site 0349)

Nice, Alpes-Maritimes, 06202, France
Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre ( Site 0037)

Greenfield Park, Quebec, J4V 2H1, Canada
Centro de Investigacion Clinica de Oaxaca ( Site 0181)

Oaxaca City, Oaxaca, 68020, Mexico
Chang Gung Medical Foundation-Linkou Branch ( Site 0243)

Taoyuan, 33305, Taiwan
Chang Gung Memorial Hospital- Chiayi ( Site 0242)

Chiayi City, Chiayi, 613, Taiwan
Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0369)

Berlin, 13353, Germany
Chinese Academy of medical science, Peking Union Medical College Hospital(Dongdan) ( Site 0675)

Beijing, Beijing Municipality, 100730, China
Chongqing University Cancer Hospital ( Site 0666)

Chongqing, Chongqing Municipality, 400030, China
Clinica Universidad de Navarra-Hematology Department ( Site 0485)

Madrid, Madrid, Comunidad de, 28027, Spain
Clínica Alemana de Santiago ( Site 0143)

Santiago, Region M. de Santiago, 7650568, Chile
Clínica Inmunocel ( Site 0147)

Santiago, Region M. de Santiago, 7580206, Chile
Clínica de Nefrología, Urología y Enfermedades Cardiovasculares ( Site 0105)

Santa Fe, 3000, Argentina
Debreceni Egyetem Klinikai Kozpont-Belgyógyászati Klinika (Haematologia) ( Site 0402)

Debrecen, 4032, Hungary
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi-Hemotology ( Site 0510)

Ankara, 06200, Turkey (Türkiye)
Duke University Health System (DUHS) ( Site 0012)

Durham, North Carolina, 27710, United States
Ege Universitesi Hastanesi ( Site 0503)

Bornova, İzmir, 35100, Turkey (Türkiye)
Ehime University Hospital ( Site 0612)

Tōon, Ehime, 791-0295, Japan
Exempla Lutheran Medical Center ( Site 0014)

Golden, Colorado, 80401, United States
FALP-UIDO ( Site 0148)

Santiago, Region M. de Santiago, 7500921, Chile
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico ( Site 0447)

Milan, 20122, Italy
Fondazione IRCCS Policlinico San Matteo-Oncology ( Site 0444)

Pavia, 27100, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 0445)

Roma, 00168, Italy
Freeman Hospital ( Site 0532)

Newcastle upon Tyne, NE7 7DN, United Kingdom
Fujita Health University Hospital ( Site 0613)

Toyoake, Aichi-ken, 470-1192, Japan
Fukushima Medical University Hospital ( Site 0616)

Fukushima, 960-1295, Japan
Fundacion Colombiana de Cancerología Clinica Vida ( Site 0164)

Medellín, Antioquia, 050030, Colombia
Galilee Medical Center ( Site 0431)

Nahariya, 2201202, Israel
Glan Clwyd Hospital ( Site 0528)

Bodelwyddan, Denbighshire, LL18 5UJ, United Kingdom
Gloucestershire Royal Hospital ( Site 0521)

Gloucester, Gloucestershire, Gl1 3NN, United Kingdom
Guy's & St Thomas' NHS Foundation Trust ( Site 0523)

London, London, City of, SE1 9RT, United Kingdom
HENRI MONDOR HOSPITAL ( Site 0348)

Créteil, Val-de-Marne, 94010, France
HOSPITAL CLÍNIC DE BARCELONA ( Site 0481)

Barcelona, Catalonia, 08036, Spain
Hacettepe Universite Hastaneleri-Department of Hematology ( Site 0505)

Ankara, 06230, Turkey (Türkiye)
Hadassah Medical Center ( Site 0424)

Jerusalem, 9112001, Israel
Hammersmith Hospital ( Site 0533)

London, London, City of, W12 OHS, United Kingdom
Henan Cancer Hospital-hematology department ( Site 0644)

Zhengzhou, Henan, 450008, China
Higiea Oncologia ( Site 0184)

Mexico City, Mexico City, 11819, Mexico
Hokkaido University Hospital ( Site 0601)

Sapporo, Hokkaido, 060-8648, Japan
Hopital Saint-Louis ( Site 0341)

Paris, 75010, France
Hospital Costa del Sol-Hematology Service ( Site 0493)

Marbella, Malaga, 29603, Spain
Hospital Germans Trias i Pujol-Instituto Catalán de Oncología de Badalona ( Site 0490)

Badalona, Barcelona, 08916, Spain
Hospital Italiano de Buenos Aires ( Site 0102)

ABB, Buenos Aires F.D., C1199ABB, Argentina
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 0489)

Barcelona, 08035, Spain
Hospital Universitario 12 de Octubre ( Site 0494)

Madrid, 28041, Spain
Hospital Universitario Austral ( Site 0101)

Pilar, Buenos Aires, B1629AHJ, Argentina
Hospital Universitario Marqués de Valdecilla-Haematology ( Site 0486)

Santander, Cantabria, 39008, Spain
Hospital Universitario Ramón y Cajal-Hematology ( Site 0484)

Madrid, Madrid, Comunidad de, 28034, Spain
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca-Hematology ( Site 0488)

Salamanca, 37007, Spain
Huashan Hospital, Fudan University ( Site 0669)

Shanghai, Shanghai Municipality, 200040, China
Hôpital de la Conception ( Site 0351)

Marseille, Bouches-du-Rhone, 13005, France
IC La Serena Research ( Site 0150)

La Serena, Coquimbo Region, 1720430, Chile
IMAT S.A.S ( Site 0162)

Montería, Departamento de Córdoba, 230002, Colombia
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 0446)

Bologna, 40138, Italy
Institut Català d'Oncologia - L'Hospitalet ( Site 0482)

L'Hospitalet de Llobregat, Barcelona, 08908, Spain
Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE ( Site 0352)

Toulouse, Haute-Garonne, 31059, France
Institute of hematology&blood disease hospital-Hematology ( Site 0641)

Tianjin, Tianjin Municipality, 301636, China
Jinan Central Hospital ( Site 0667)

Jinan, Shandong, 250013, China
Juntendo University Hospital ( Site 0611)

Bunkyo-ku, Tokyo, 113-8431, Japan
Kanazawa University Hospital ( Site 0614)

Kanazawa, Ishikawa-ken, 920-8641, Japan
Kansai Medical University Hospital ( Site 0607)

Hirakata, Osaka, 573-1191, Japan
Karolinska Universitetssjukhuset Huddinge ( Site 0541)

Huddinge, Stockholm County, 141 86, Sweden
Kindai University Hospital ( Site 0600)

Sakai, Osaka, 590-0197, Japan
Kobe City Medical Center General Hospital ( Site 0603)

Kobe, Hyōgo, 650-0047, Japan
Kocaeli Üniversitesi-Hematology ( Site 0506)

Kocaeli, 41380, Turkey (Türkiye)
Kyushu University Hospital ( Site 0605)

Fukuoka, 812-8582, Japan
Levine Cancer Institute ( Site 0009)

Charlotte, North Carolina, 28204, United States
Lincoln County Hospital ( Site 0535)

Lincoln, Great Britain, LN2 5QY, United Kingdom
Los Angeles Cancer Network ( Site 0025)

Glendale, California, 91206, United States
Los Cobos Medical Center ( Site 0165)

Bogotá, Bogota D.C., 110121, Colombia
Medipol Mega Universite Hastanesi ( Site 0504)

Istanbul, 34214, Turkey (Türkiye)
Medivest Centro de Investigación Integral ( Site 0183)

Chihuahua City, Chihuahua, 31203, Mexico
Medizinische Hochschule Hannover ( Site 0371)

Hanover, Lower Saxony, 30625, Germany
Mie University Hospital ( Site 0615)

Tsu, Mie-ken, 514-8507, Japan
Monash Health-Haematology Research ( Site 0202)

Clayton, Victoria, 3168, Australia
National Cheng Kung University Hospital-Clinical Trial Center ( Site 0245)

Tainan, 704, Taiwan
National Hospital Organization Sendai Medical Center ( Site 0617)

Sendai, Miyagi, 983-8520, Japan
National Taiwan University Hospital ( Site 0241)

Taipei, 10002, Taiwan
Nippon Medical School Hospital ( Site 0608)

Tokyo, 113-8603, Japan
Odense Universitetshospital-Department of Hematology ( Site 0325)

Odense C, Region Syddanmark, 5000, Denmark
Okayama University Hospital ( Site 0604)

Okayama, 700-8558, Japan
Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8005)

Eugene, Oregon, 97401, United States
Ondokuz Mayıs Universitesi-hematology ( Site 0507)

Samsun, 55139, Turkey (Türkiye)
Optum Care Cancer Center ( Site 0053)

Las Vegas, Nevada, 89102, United States
Ordensklinikum Linz GmbH Elisabethinen ( Site 0562)

Linz, Upper Austria, 4020, Austria
Oregon Health & Science University ( Site 0018)

Portland, Oregon, 97239, United States
Ospedale di Circolo e Fondazione Macchi Varese ( Site 0442)

Varese, 21100, Italy
Palo Verde Cancer Specialists ( Site 0052)

Glendale, Arizona, 85304, United States
Parkview Research Center at Parkview Regional Medical Center ( Site 0006)

Fort Wayne, Indiana, 46845, United States
Peking University Third Hospital-Hematology ( Site 0659)

Beijing, Beijing Municipality, 100191, China
Petz Aladar Egyetemi Oktato Korhaz-Hematológia ( Site 0405)

Győr, Győr-Moson-Sopron, 9024, Hungary
Pratia Onkologia Katowice ( Site 0461)

Katowice, Silesian Voivodeship, 40-519, Poland
Queen Mary Hospital ( Site 0221)

Hksar, Hong Kong
Rabin Medical Center ( Site 0425)

Petah Tikva, 4941492, Israel
Rambam Health Care Campus ( Site 0429)

Haifa, 3109601, Israel
Rigshospitalet-Hematology - CTU ( Site 0321)

Copenhagen, Capital Region, 2100, Denmark
Roskilde Sygehus-Department of Hematology ( Site 0323)

Roskilde, Region Sjælland, 4000, Denmark
Royal Adelaide Hospital-Haematology Clinical Trials Unit ( Site 0203)

Adelaide, South Australia, 5000, Australia
Royal Gwent Hospital ( Site 0524)

Newport, NP20 2EF, United Kingdom
Royal Perth Hospital-Haematology ( Site 0204)

Perth, Western Australia, 6000, Australia
Sahlgrenska Universitetssjukhuset-Department of hematology and coagulation ( Site 0543)

Gothenburg, Västra Götaland County, 413 45, Sweden
Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie-Oddział Hematoonkologii, Transplantacji Szp ( Site 0463)

Lublin, Lublin Voivodeship, 20-081, Poland
Shaanxi provincial people's hospital ( Site 0652)

Xi'an, Shaanxi, 710068, China
Sheba Medical Center ( Site 0428)

Ramat Gan, 5265601, Israel
Skånes Universitetssjukhus Lund-Department of Hematology ( Site 0544)

Lund, Skåne County, 22185, Sweden
Somogy Vármegyei Kaposi Mór Oktató Kórház-Haematológiai osztály ( Site 0406)

Kaposvár, Somogy County, 7400, Hungary
Soroka Medical Center ( Site 0427)

Beersheba, 8410101, Israel
Sourasky Medical Center ( Site 0422)

Tel Aviv, 6423906, Israel
Southern Medical University Nanfang Hospital-Department of Hematopathology ( Site 0655)

Guangzhou, Guangdong, 510515, China
Stanford Cancer Center ( Site 0024)

Palo Alto, California, 94304, United States
Sun Yat-sen Memorial Hospital, Sun Yat-sen University-hematology department ( Site 0668)

Guangzhou, Guangdong, 510120, China
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Hematologii i Transplantacji S ( Site 0466)

Kielce, Świętokrzyskie Voivodeship, 25-734, Poland
Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókór-Haematológia osztály ( Site 0404)

Nyíregyháza, Szabolcs-Szatmár-Bereg, 4400, Hungary
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Belgyógyászati Klinika ( Site 0407)

Szeged, Csongrád megye, 6725, Hungary
Texas Oncology - DFW ( Site 8006)

Dallas, Texas, 75246, United States
Texas Oncology - Gulf Coast ( Site 8008)

Webster, Texas, 77598, United States
Texas Oncology - West Texas ( Site 8003)

Amarillo, Texas, 79124, United States
The First Affiliated Hospital of Soochow University ( Site 0676)

Suzhou, Jiangsu, 215006, China
The First Affiliated hospital of Xiamen University ( Site 0658)

Xiamen, Fujian, 361003, China
The First Afflilated Hospital of Bengbu Medical College ( Site 0651)

Bengbu, Anhui, 233004, China
The First Hospital of Hebei Medical University ( Site 0649)

Shijiazhuang, Hebei, 050031, China
The First Hospital of Jilin University-Hematology ( Site 0672)

Changchun, Jilin, 130021, China
The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 0645)

Nanchang, Jiangxi, 330209, China
The Ohio State University Wexner Medical Center ( Site 0028)

Columbus, Ohio, 43210, United States
The Second Affiliated Hospital of Fujian Medical University ( Site 0671)

Quanzhou, Fujian, 362000, China
The Second Afilliated Hospital of Hebei Medical University ( Site 0650)

Shijiazhuang, Hebei, 050000, China
The first Affiliated Hospital, Zhejiang University School of Medicine ( Site 0646)

Hangzhou, Zhejiang, 310000, China
Trakya University Medical Faculty Hospital-Hematology ( Site 0501)

Edirne, 22030, Turkey (Türkiye)
TriStar Bone Marrow ( Site 7000)

Nashville, Tennessee, 37203, United States
Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 0642)

Wuhan, Hubei, 430022, China
Universitaetsklinikum Essen ( Site 0366)

Essen, North Rhine-Westphalia, 45147, Germany
Universitetssjukhuset Örebro ( Site 0542)

Örebro, Örebro County, 701 85, Sweden
University College London Hospital ( Site 0527)

London, London, City of, NW1 2PG, United Kingdom
University of Michigan ( Site 0003)

Ann Arbor, Michigan, 48109, United States
University of Miyazaki Hospital ( Site 0609)

Miyazaki, 889-1692, Japan
University of Texas Health Science Center at San Antonio ( Site 0021)

San Antonio, Texas, 78229, United States
University of Texas MD Anderson Cancer Center ( Site 0026)

Houston, Texas, 77030, United States
University of Virginia ( Site 0020)

Charlottesville, Virginia, 22908, United States
University of Yamanashi Hospital ( Site 0606)

Chūō, Yamanashi, 409-3898, Japan
Universitätsklinikum Aachen ( Site 0367)

Aachen, North Rhine-Westphalia, 52074, Germany
Universitätsklinikum Halle ( Site 0361)

Halle, Saxony-Anhalt, 06120, Germany
Universitätsklinikum Jena-Klinik für Innere Medizin II, Abt. Hämatologie und Internistische Onkolog ( Site 0364)

Jena, Thuringia, 07747, Germany
Universitätsmedizin Johannes Gutenberg Universität Mainz-3. Medizinische Klinik und Poliklinik ( Site 0365)

Mainz, Rhineland-Palatinate, 55131, Germany
VCU Health Adult Outpatient Pavillion ( Site 0008)

Richmond, Virginia, 23219, United States
VK&K Studien GbR ( Site 0370)

Landshut, Bavaria, 84036, Germany
Wake Forest Baptist Health-Internal Medicine, Section on Hematology & Oncology ( Site 0013)

Winston-Salem, North Carolina, 27157, United States
West China Hospital, Sichuan University ( Site 0661)

Chengdu, Sichuan, 610041, China
Westmead Hospital ( Site 0201)

Westmead, New South Wales, 2115, Australia
Yale University School of Medicine ( Site 0051)

New Haven, Connecticut, 06510, United States
Yitzhak Shamir Medical Center. ( Site 0421)

Ẕerifin, 7033001, Israel
Zhejiang University School of Medicine-The Fourth Affiliated Hospital ( Site 0662)

Yiwu, Zhejiang, 322000, China
Zhongshan Hospital,Fudan University-Hematology ( Site 0674)

Shanghai, Shanghai Municipality, 200032, China
centre hospitalier lyon sud ( Site 0343)

Pierre-Bénite, Rhone, 69310, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.