New combo therapy takes on tough lung cancer

NCT ID NCT06449209

Ongoing Disease control Sponsor: BioNTech SE Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial is testing an experimental drug called BNT327 combined with standard chemotherapy in 110 people with small-cell lung cancer. One group has untreated extensive-stage disease, while others have cancer that returned after prior treatment. The study aims to see if the combination is safe and can shrink tumors. Results will help decide if larger studies are warranted.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BNT327 (an experimental drug) combined with chemotherapy drugs (etoposide, carboplatin, paclitaxel, or topotecan)
What this could lead to: If successful, this could point toward a new treatment option for people with small-cell lung cancer, potentially improving tumor shrinkage and disease control.
What could go wrong: This is an early Phase 2 trial with only 110 participants, so results may not apply to everyone. The drug combination may cause side effects or fail to show better outcomes than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXTENSIVE-STAGE SMALL CELL LUNG CANCER SMALL CELL LUNG CANCER

Contacts and locations

Locations

Acibadem Adana Hastanesi

Istanbul, 34457, Turkey (Türkiye)
Adana City Training and Research Hospital

Adana, 4522, Turkey (Türkiye)
Ajou University Hospital

Suwon, 16499, South Korea
Alaska Oncology and Hematology, LLC

Anchorage, Alaska, 99508, United States
Allina Health

Minneapolis, Minnesota, 55407, United States
Ankara City Hospital

Ankara, 06800, Turkey (Türkiye)
Ankara Etlik Sehir Hastanesi

Ankara, 06170, Turkey (Türkiye)
Baskent University Hospital Adana Dr Turgut Noyan Research Center

Adana, 01120, Turkey (Türkiye)
Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi

Istanbul, 34093, Turkey (Türkiye)
Carle Foundation Hospital d/b/a Carle Cancer Center

Urbana, Illinois, 61801, United States
Chungbuk National University Hospital

Cheongju-si, 28644, South Korea
Clermont Oncology Center

Clermont, Florida, 34711, United States
Clinical Research Alliance Inc

Westbury, New York, 11590, United States
Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital

Ankara, 06200, Turkey (Türkiye)
FirstHealth Outpatient Cancer Center

Pinehurst, North Carolina, 28374, United States
Fort Wayne Medical Oncology and Hematology, Inc

Fort Wayne, Indiana, 46804, United States
Gachon University Gil Medical Center

Incheon, 21565, South Korea
Gazi University Medical Faculty

Yenimahalle, 06560, Turkey (Türkiye)
Gaziantep Sanko University Medical Faculty

Gaziantep, 36020, Turkey (Türkiye)
Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi

Istanbul, 34722, Turkey (Türkiye)
Gulhane Egitim ve Arastirma Hastanesi

Ankara, 06010, Turkey (Türkiye)
Gyeongsang National University Hospital (GNUH)

Jinju, 52727, South Korea
Hacettepe University Medical Faculty Oncology Hospital

Ankara, 06230, Turkey (Türkiye)
Haywood Infusion Center

Clyde, North Carolina, 28721-8046, United States
Hematology Oncology Associates of Treasure Coast

Port Saint Lucie, Florida, 34952, United States
Huddersfield Royal Infirmary - Calderdale and Huddersfield NHS Foundation Trust

Huddersfield, HD3 3EA, United Kingdom
Koc Universitesi Hastanesi (Koc University Hospital)

Istanbul, 34010, Turkey (Türkiye)
Kocaeli Universitesi Tip Fakultesi

Kocaeli, 41380, Turkey (Türkiye)
Korea University Anam Hospital

Seoul, 02841, South Korea
Liv Hospital

Ankara, 06680, Turkey (Türkiye)
Lyell McEwin Hospital

Adelaide, 5112, Australia
Medical Park Seyhan Hospital

Adana, 01230, Turkey (Türkiye)
Medical Point Izmir Hospital

Izmir, 35325, Turkey (Türkiye)
Memorial Ankara Hospital

Ankara, 06520, Turkey (Türkiye)
Millenium Research & Clinical Development

Houston, Texas, 77090, United States
Namik Kemal University Hospital

Tekirdağ, 59030, Turkey (Türkiye)
National Cancer Center

Goyang-si, 10408, South Korea
Nebraska Hematology-Oncology (NHO) - Lincoln

Lincoln, Nebraska, 68506, United States
Ninewells Hospital and Medical School - Tayside Health Board

Dundee, DD1 9SY, United Kingdom
Northern Centre for Cancer Care,The Newcastle Upon Tyne Hospitals NHS Foundation Trust

Newcastle upon Tyne, NE7 7DN, United Kingdom
Nottingham University Hospitals NHS Trust

Nottingham, NG5 1PB, United Kingdom
Peninsula Oncology Centre

Frankston, 3199, Australia
Queen Elizabeth Hospital Birmingham - University Hospitals Birmingham NHS Foundation Trust

Birmingham, B15 2GW, United Kingdom
Royal Devon and Exeter Hospital, Wonford - Royal Devon And Exeter NHS Foundation Trust

Exeter, EX2 5DW, United Kingdom
Royal North Shore Hospital

St Leonards, 2065, Australia
Royal Preston Hospital - Lancashire Teaching Hospitals NHS Foundation Trust

Preston, PR2 9HT, United Kingdom
Royal Stoke University Hospital - University Hospitals of North Midlands NHS Trust

Stoke-on-Trent, ST4 6QG, United Kingdom
SSM Health Cancer Care

Madison, Wisconsin, 53715, United States
SSM Health Cancer Care - St. Clare

Fenton, Missouri, 63026, United States
Sakarya University - Faculty of Medicine

Sakarya, 54290, Turkey (Türkiye)
Sarah Cannon Research Institute

London, W1G 6AD, United Kingdom
Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea
St James's University Hospital - Leeds Teaching Hospitals NHS Trust

Leeds, LS9 7TF, United Kingdom
St. Vincent's Hospital

Fitzroy, 3065, Australia
Tallahassee Memorial Physician Partners - Cancer & Hematology Specialists

Tallahassee, Florida, 32308, United States
The Catholic University of Korea Seoul St. Mary's Hospital

Seoul, 06591, South Korea
The Christ Hospital Cancer Center

Cincinnati, Ohio, 45219, United States
University of Kentucky Chandler Medical Center (UKCMC) - Markey Cancer Center (Lucille P. Markey Cancer Center)

Lexington, Kentucky, 40536, United States
University of Tennessee Medical Center

Knoxville, Tennessee, 37920, United States
Valkyrie Clinical Trials

Los Angeles, California, 90067, United States
Velindre Hospital - Velindre NHS Trust

Cardiff, CF14 2TL, United Kingdom
Westmead Hospital

Westmead, 2145, Australia
Yeditepe University Kosuyolu Hospital

Istanbul, 34718, Turkey (Türkiye)
Yeungnam University Medical Center

Daegu, 42415, South Korea

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