New pill could quiet chronic cough that just Won't stop

NCT ID NCT05600777

Ongoing Symptom relief Sponsor: Bellus Health Inc. - a GSK company Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 15, 2026 · Updated 3 times

Summary

This phase 3 study tests an experimental drug called BLU-5937 (camlipixant) in about 975 adults with refractory chronic cough, including unexplained chronic cough. Participants receive either the drug or a placebo for 24 weeks, and researchers measure how much coughing decreases and monitor for side effects. The goal is to see if this drug can safely reduce coughing in people who haven't found relief from other treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BLU-5937 (camlipixant)
What this could lead to: If it works, this could provide a new treatment option to reduce coughing in people with chronic cough that hasn't responded to other therapies.
What could go wrong: This is a late-stage trial, but the drug may still fail to show meaningful benefit or cause side effects like taste disturbance or oral numbness. Results may not apply to all cough patients.

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Conditions

The condition(s) this trial relates to.

Chronic Cough Cough Respiration Disorders respiratory system disorder Signs and Symptoms, Respiratory

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COUGH REFRACTORY CHRONIC COUGH

Contacts and locations

Locations

GSK Investigational Site

Foley, Alabama, 36535, United States
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Litchfield Park, Arizona, 85340, United States
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Phoenix, Arizona, 85032, United States
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Los Angeles, California, 90025, United States
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Los Angeles, California, 90048, United States
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Paramount, California, 90723, United States
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Sacramento, California, 95661, United States
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San Diego, California, 92108, United States
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San Diego, California, 92120, United States
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San Jose, California, 95117, United States
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Aurora, Colorado, 80012, United States
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Colorado Springs, Colorado, 80923, United States
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Denver, Colorado, 80230, United States
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Wheat Ridge, Colorado, 96001, United States
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Washington D.C., District of Columbia, 20007, United States
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Daytona Beach, Florida, 32117, United States
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Fort Lauderdale, Florida, 33324, United States
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Jacksonville, Florida, 32224, United States
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Leesburg, Florida, 34748, United States
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Orlando, Florida, 32713, United States
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Santa Rosa Beach, Florida, 32459, United States
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Sarasota, Florida, 34239, United States
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Sweetwater, Florida, 33172, United States
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Cumming, Georgia, 30041, United States
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Chicago, Illinois, 60612, United States
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River Forest, Illinois, 60305, United States
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West Des Moines, Iowa, 50266, United States
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Lexington, Kentucky, 40509, United States
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Chevy Chase, Maryland, 20815, United States
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Methuen, Massachusetts, 01844, United States
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North Dartmouth, Massachusetts, 02747, United States
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Ypsilanti, Michigan, 48197, United States
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Edina, Minnesota, 55435, United States
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Woodbury, Minnesota, 55125, United States
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St Louis, Missouri, 55905, United States
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St Louis, Missouri, 63141, United States
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Missoula, Montana, 59808, United States
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Omaha, Nebraska, 68124, United States
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Charlotte, North Carolina, 28211, United States
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Gastonia, North Carolina, 28054, United States
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Winston-Salem, North Carolina, 27103, United States
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Columbus, Ohio, 43235, United States
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Tulsa, Oklahoma, 74136, United States
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Portland, Oregon, 97213, United States
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Danville, Pennsylvania, 17822, United States
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Philadelphia, Pennsylvania, 19107, United States
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Warwick, Rhode Island, 02886, United States
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Anderson, South Carolina, 29621, United States
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Charleston, South Carolina, 29406, United States
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Charleston, South Carolina, 29412, United States
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Franklin, Tennessee, 37067, United States
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Dallas, Texas, 75231-4307, United States
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Round Rock, Texas, 78681, United States
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San Antonio, Texas, 78207, United States
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San Antonio, Texas, 78258, United States
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Norfolk, Virginia, 23507, United States
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Bellingham, Washington, 98225, United States
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Coffs Harbour, New South Wales, 2450, Australia
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Macquarie University, New South Wales, 2109, Australia
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New Lambton Heights, New South Wales, 2305, Australia
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St Leonards, New South Wales, 2065, Australia
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Chermside, Queensland, 4032, Australia
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Adelaide, South Australia, 5000, Australia
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St Albans, Victoria, 3021, Australia
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Nedlands, Western Australia, 6009, Australia
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Spearwood, Western Australia, 6163, Australia
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Calgary, Alberta, T2N 1N4, Canada
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Ajax, Ontario, L1S 2J5, Canada
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Hamilton, Ontario, L8L 5G4, Canada
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Hamilton, Ontario, L8N 3Z5, Canada
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Toronto, Ontario, M5T 3A9, Canada
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Windsor, Ontario, N8X 1T3, Canada
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Montreal, Quebec, H1Y3H5, Canada
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Québec, Quebec, G1V 4T3, Canada
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Québec, Quebec, G1V 4W2, Canada
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Saint-Charles-Borromée, Quebec, J6E 2B4, Canada
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Trois-Rivières, Quebec, G8T 7A1, Canada
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Victoriaville, Quebec, G6P 3Z8, Canada
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Burlington, ON L7N 3V2, Canada
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Kunshan, Jiangsu, China
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Leshan, Sichuan, 614003, China
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Ürümqi, Xinjiang, 830001, China
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Beijing, 100730, China
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Changsha, 410008, China
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Chengdu, 610021, China
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Chengdu, 610041, China
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Chongqing, 408099, China
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Dongguan, 523326, China
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Ganzhou, 341000, China
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Guangzhou, 510000, China
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Guangzhou, 510260, China
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Guilin, 541002, China
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Hangzhou, 310003, China
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Hefei, 230001, China
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Hefei, 230022, China
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Hohhot, 010017, China
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Huizhou, 516000, China
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Huizhou, 516001, China
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Jiangsu, 221004, China
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Jinan, 250021, China
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Jingzhou, 434020, China
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Kunming, 650032, China
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Liuzhou, China
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Meizhou, 514700, China
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Nanchang, 330038, China
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Pingxiang, 337055, China
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Shanghai, 200032, China
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Shanghai, 200065, China
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Shanghai, 200080, China
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Shenyang, 110004, China
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Shenzhen, 518053, China
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Taizhou, 317000, China
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Weifang, China
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Wenzhou, 325000, China
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Wuxi, 214023, China
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Xiamen, 361004, China
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Yangzhou, 225001, China
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Yinchuan, China
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Zhanjiang, 524045, China
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Zhengzhou, 450052, China
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Kralupy nad Vltavou, 278 01, Czechia
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Strakonice, 38601, Czechia
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Berlin, 10117, Germany
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Berlin, 10969, Germany
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Bochum, 44787, Germany
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Darmstadt, 64283, Germany
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Dresden, 01069, Germany
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Essen, 45355, Germany
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Frankfurt, 60590, Germany
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Frankfurt, 60596, Germany
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Frankfurt am Main, 60315, Germany
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Geesthacht, 21502, Germany
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Halle, 6108, Germany
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Hamburg, 20253, Germany
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Hanover, 30159, Germany
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Hanover, 30173, Germany
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Heidelberg, 69126, Germany
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Karlsruhe, 76137, Germany
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Lübeck, 23552, Germany
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Marburg, 35037, Germany
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München, 81241, Germany
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Neu-Isenburg, 63263, Germany
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Peine, 31224, Germany
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Schleswig, 24837, Germany
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Wallerfing, 94574, Germany
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Wiesbaden, 65205, Germany
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Belagavi, 590010, India
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Faridabad, 121006, India
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Nagpur, 44009, India
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Nashik, 422001, India
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Visakhapatnam, 530017, India
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Aichi, 460-0001, Japan
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Aichi, 467-8602, Japan
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Akita, 010-8543, Japan
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Chiba, 260-8677, Japan
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Fukui, 910-1193, Japan
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Fukuoka, 807-8556, Japan
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Fukuoka, 812-8582, Japan
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Fukuoka, 819-8555, Japan
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Fukushima, 960-1295, Japan
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Gifu, 153-8515, Japan
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Gifu, 501-6062, Japan
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Gifu, 509-6134, Japan
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Hiroshima, 730-0853, Japan
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Hiroshima, 735-8585, Japan
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Hokkaido, 064-0804, Japan
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Hyōgo, 663-8501, Japan
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Hyōgo, 670-8520, Japan
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Hyōgo, 672-8064, Japan
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Hyōgo, 674-0063, Japan
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Ibaraki, 319-1113, Japan
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Kagoshima, 890-8520, Japan
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Kanagawa, 231-8682, Japan
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Kanagawa, 232-0024, Japan
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Kanagawa, 234-8503, Japan
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Kyoto, 606-8507, Japan
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Kyoto, 612-8555, Japan
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Mie, 515-8544, Japan
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Miyazaki, 889-4304, Japan
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Nagasaki, 852-8501, Japan
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Nankoku-shi, 783-8509, Japan
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Niigata, 950-1197, Japan
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Osaka, 545-8586, Japan
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Osaka, 577-0843, Japan
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Osaka, 589-8511, Japan
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Osaka, 591-8555, Japan
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Saitama, 350-0495, Japan
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Shizuoka, 420-8527, Japan
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Shizuoka, 426-8677, Japan
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Shizuoka, 432-8002, Japan
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Shizuoka, 433-8558, Japan
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Tochigi, 321-0293, Japan
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Tokyo, 104-0031, Japan
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Tokyo, 140-8522, Japan
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Tokyo, 150-8935, Japan
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Tokyo, 173-8606, Japan
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Tokyo, 204-8522, Japan
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Toyama, 930-8550, Japan
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Yokohama, 236-0004, Japan
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Havelock North, Hawke's Bay Region, 3410, New Zealand
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Ebdentown, Upper Hutt, 5018, New Zealand
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Christchurch, 8011, New Zealand
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Kapiti, 5036, New Zealand
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Nelson, 7011, New Zealand
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Rotorua, 3010, New Zealand
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Tauranga, 3110, New Zealand
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Bardejov, 8501, Slovakia
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Busan, 49241, South Korea
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Incheon, 21431, South Korea
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Jeonju, 54907, South Korea
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Seongnam, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 03312, South Korea
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Seoul, 03722, South Korea
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Seoul, 06591, South Korea
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Seoul, 08308, South Korea
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Seoul, 133-792, South Korea
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Seoul, 5030, South Korea
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Seoul, 5505, South Korea
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Seoul, 6351, South Korea
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Wŏnju, 26426, South Korea
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Changhua, 50006, Taiwan
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Kaohsiung City, 807, Taiwan
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Kaohsiung City, 82445, Taiwan
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Taoyuan County, 333, Taiwan
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Belfast, BT7 2EB, United Kingdom
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Bradford, BD9 6RJ, United Kingdom
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Bristol, BS374AX, United Kingdom
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Chelmsford, CM1 7ET, United Kingdom
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Corby, NN17 2UR, United Kingdom
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Corby, NN18 9EZ, United Kingdom
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Coventry, CV3 4FJ, United Kingdom
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Hayle, TR27 5DT, United Kingdom
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Hull, HU16 5JQ, United Kingdom
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London, SE5 9RS, United Kingdom
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Northwood, HA6 2RN, United Kingdom
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Orpington, BR5 3QG, United Kingdom
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Peterborough, PE3 9GZ, United Kingdom
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Preston, PR2 9HT, United Kingdom
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Shipley, BD18 3SA, United Kingdom
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Tyne and Wear, NE29 8NH, United Kingdom
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Wishaw, ML2 0DP, United Kingdom

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