Which pill works best for bipolar depression? major study aims to find out

NCT ID NCT06433635

First seen Jan 06, 2026 · Last updated May 05, 2026 · Updated 15 times

Summary

This study compares four commonly prescribed medications for bipolar depression in over 2,700 adults. The goal is to see which treatment helps people feel better and return to a normal mood. Participants will be randomly assigned to one of the four drugs and monitored for improvement.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Case Western Reserve University

    Cleveland, Ohio, 44106-1712, United States

  • John Hopkins

    Baltimore, Maryland, 21218, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • McLean Hospital

    Belmont, Massachusetts, 02478, United States

  • Montefiore Medical Center and Albert Einstein College of Medicine

    New York, New York, 10461, United States

  • Nagy Youssef

    Grand Rapids, Michigan, 49548, United States

  • New York University Grossman School of Medicine NYU

    New York, New York, 10016, United States

  • Steve Strakowski

    Bloomington, Indiana, 47405, United States

  • UT Health Houston Texas

    Houston, Texas, 77030, United States

  • UT Southwestern Medical Center

    Dallas, Texas, 75390-7208, United States

  • University of Alabama Birmingham

    Birmingham, Alabama, 35294, United States

  • University of British Columbia

    Vancouver, British Columbia, V6T 1Z4, Canada

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

  • University of New Mexico Health Sciences Center Albuquerque

    Albuquerque, New Mexico, 87131-0001, United States

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27599, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Pittsburgh

    Pittsburgh, Pennsylvania, 15260, United States

  • University of Texas at Austin

    Austin, Texas, 78712, United States

Conditions

Explore the condition pages connected to this study.