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Which dental biomaterial works best when left exposed in the mouth?

NCT ID NCT07589751

Knowledge-focused Sponsor: Pontificia Universidade Católica do Rio Grande do Sul Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

After a tooth is pulled, the bone can shrink, making it harder to place dental implants later. This study tests two collagen-based biomaterials that are left exposed to the mouth to see how well they preserve bone. Sixty adults needing a single tooth extraction will be randomly assigned to one of two biomaterials or natural healing. Researchers will measure bone changes, bacterial contamination, and patient comfort to help dentists choose the best option.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Bio-Oss Collagen® and Bio-Gide® or Mucograft® Seal®
What this could lead to
If successful, this could help dentists choose safer biomaterials for preserving bone after tooth extraction, improving future dental implant success.
What could go wrong
This is a small, early-stage study with only 60 participants, so results may not apply to all patients. The biomaterials are left exposed to saliva and bacteria, which could affect healing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult subjects in need of non-molar maxillary or mandibular single tooth extraction at the PUCRS university - Porto Alegre - Brazil. 1. \> 18 years of age 2. non-molar tooth indicated for extraction 3. intact sockets upon extractions 4. Patients using removable provisional prosthesis (accessible to remove possible contact with surgical site) or patients without prosthesis after tooth extraction. Exclusion Criteria: 1. Current smokers 2. Uncontrolled Diabetes Mellitus 3. Mandibular incisors 4. Patients receiving chemo or radiotherapy or history of these treatments in the previous 5 years 5. Any other disease or medications that may compromise normal wound healing 6. Unwilling or unable to sing the informed consent

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alveolar ridge preservation Tooth extraction site healing

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • PUCRS

    Porto Alegre, Rio Grande do Sul, 90619900, Brazil

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