Experimental drug combo targets brain tumors from lung cancer

NCT ID NCT02589522

First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 27 times

Summary

This early-phase trial is testing the safety and best dose of a drug called berzosertib when given together with whole brain radiation therapy. It includes 15 adults with lung cancer that has spread to the brain. The goal is to find out if adding the drug to radiation is safe and to look for any side effects.

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Contacts and locations

Locations

  • Case Western Reserve University

    Cleveland, Ohio, 44106, United States

  • City of Hope Comprehensive Cancer Center

    Duarte, California, 91010, United States

  • Johns Hopkins University/Sidney Kimmel Cancer Center

    Baltimore, Maryland, 21287, United States

  • Mayo Clinic in Florida

    Jacksonville, Florida, 32224-9980, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • University of Kentucky/Markey Cancer Center

    Lexington, Kentucky, 40536, United States

  • University of Maryland/Greenebaum Cancer Center

    Baltimore, Maryland, 21201, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.