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Can a monthly shot help people with obesity lose weight?

NCT ID NCT07794774

Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 31, 2026 · Last updated Sep 04, 2026 · Updated 2 times

Summary

This study tests an experimental drug called berobenatide, given as a once-monthly injection, to see if it helps adults with obesity lose weight. About 197 participants in Japan will receive either berobenatide or a placebo for roughly 21 months. The trial measures changes in body weight, waist size, and other health markers, and also checks the drug's safety.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
berobenatide, an experimental once-monthly injectable drug
What this could lead to
If it works, this could offer a convenient once-monthly option for weight loss in people with obesity, potentially reducing related health risks.
What could go wrong
This is a Phase 3 trial, but success is not guaranteed. The drug may cause side effects, and results in this Japanese population may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 197 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Feb 2029

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged ≥18 years. * BMI of: ≥27.0 kg/m2 to \<35.0 kg/m2 with ≥2 obesity-related health disorders or BMI of ≥35.0 kg/m2 with ≥1 obesity-related health disorder. The participant must have at least one of either hypertension, dyslipidemia or glucose intolerance (T2D and impaired glucose tolerance etc.) as an obesity-related health disorder. Exclusion Criteria: * Have a self-reported body weight change greater than 5% within 90 days prior to Screening. * Diagnosis of type 1 diabetes or any other form of diabetes other than T2D. * History of acute or chronic pancreatitis. * Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN-2).

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    11 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Fukuwa Clinic

    Chuo-ku, Tokyo, 104-0031, Japan

  • Higashi-Shinjuku Clinic, Keikokai Medical Corp.

    Shinjuku-ku, Tokyo, 169-0072, Japan

  • Ikebukuro Metropolitan Clinic

    Toshima-ku, Tokyo, 171-0021, Japan

  • Manda Memorial Hospital

    Sapporo, Hokkaido, 060-0062, Japan

  • Medical Corporation Heishinkai OCROM Clinic

    Suita, Osaka, 565-0853, Japan

  • Medical Corporation Heishinkai ToCROM Clinic

    Shinjuku-ku, Tokyo, 160-0008, Japan

  • Nihonbashi Sakura Clinic

    Tokyo, 103-0025, Japan

  • Oishi Clinic

    Kasuya-gun, Fukuoka, 811-2310, Japan

  • Shimamura Memorial Hospital

    Nerima-ku, Tokyo, 177-0051, Japan

  • Tokyo Center Clinic

    Chuo-ku, Tokyo, 103-0027, Japan

  • Tokyo-Eki Center-building Clinic

    Chuo-ku, Tokyo, 103-0027, Japan

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