New hope for advanced breast cancer: drug combo targets tumors after hormone therapy fails

NCT ID NCT06428396

Ongoing Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study tests whether adding belzutifan to fulvestrant can slow or stop the growth of a certain type of advanced breast cancer (ER+/HER2-) that has worsened despite hormone therapy. About 120 adults with inoperable or metastatic disease will receive either the new combination or standard treatment. The goal is to see if the new approach delays cancer progression.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm estrogen-receptor positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC BREAST CANCER

Contacts and locations

Locations

Bradfordhill ( Site 4100)

Santiago, Region M. de Santiago, 8420383, Chile
CHRISTUS Highland ( Site 0005)

Shreveport, Louisiana, 71105, United States
Cedars Sinai Medical Center ( Site 0012)

Beverly Hills, California, 90211, United States
Centro de Investigaciones Metabólicas (CINME)-Oncology ( Site 0504)

CABA, Buenos Aires, C1056ABI, Argentina
Centro de Investigación del Maule ( Site 4106)

Talca, Maule Region, 3460000, Chile
City of Hope - Phoenix ( Site 0006)

Goodyear, Arizona, 85338, United States
FALP ( Site 4102)

Santiago, Region M. de Santiago, 7500921, Chile
Faculty of Medicine - Khon Kaen University ( Site 3502)

Muang, Changwat Khon Kaen, 40002, Thailand
Faculty of Medicine Siriraj Hospital ( Site 3500)

Bangkoknoi, Bangkok, 10700, Thailand
Fundacion Valle del Lili ( Site 1204)

Cali, Valle del Cauca Department, 760032, Colombia
Hospital Británico de Buenos Aires-Oncology ( Site 0500)

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1280AEB, Argentina
Hospital Italiano de Córdoba ( Site 0508)

Córdoba, X5004BAL, Argentina
IMAT S.A.S ( Site 1205)

Montería, Departamento de Córdoba, 230002, Colombia
Instituto Alexander Fleming-Alexander Fleming ( Site 0505)

Buenos Aires, Buenos Aires F.D., C1426ANZ, Argentina
Instituto de Investigaciones Clínicas Mar del Plata ( Site 0502)

Mar del Plata, Buenos Aires, B7600FZO, Argentina
Instituto de Oncología de Rosario ( Site 0501)

Rosario, Santa Fe Province, S2000KZE, Argentina
Ipswich Hospital ( Site 1911)

Ipswich, Suffolk, IP4 5PD, United Kingdom
Jewish General Hospital ( Site 0400)

Montreal, Quebec, H3T 1E2, Canada
MD Anderson ( Site 0015)

Houston, Texas, 77030, United States
MD Anderson Cancer Center at Cooper ( Site 0024)

Camden, New Jersey, 08103, United States
Mays Cancer Center ( Site 0022)

San Antonio, Texas, 78229, United States
Medical College of Wisconsin - Froedtert Hospital ( Site 0014)

Milwaukee, Wisconsin, 53226, United States
Moores Cancer Center at UC San Diego Health ( Site 0025)

La Jolla, California, 92093, United States
National Cheng Kung University Hospital ( Site 3300)

Tainan, 704302, Taiwan
National Taiwan University Cancer Center ( Site 3302)

Taipei, 106, Taiwan
National Taiwan University Hospital ( Site 3301)

Taipei, 10002, Taiwan
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 0011)

Marietta, Georgia, 30060, United States
Oncologos Del Occidente ( Site 1200)

Pereira, Risaralda Department, 660001, Colombia
Pontificia Universidad Catolica de Chile ( Site 4108)

Santiago, Region M. de Santiago, 8330024, Chile
Renown Regional Medical Center ( Site 0018)

Reno, Nevada, 89502, United States
SSM Health Dean Medical Group - South Madison Campus Health Research/Circuit Clinical ( Site 0034)

Madison, Wisconsin, 53715, United States
Samsung Medical Center ( Site 3101)

Seoul, 06351, South Korea
Sanatorio Allende - Cerro-Oncology ( Site 0506)

Córdoba, Córdoba Province, 5000, Argentina
Seoul National University Hospital ( Site 3100)

Seoul, 03080, South Korea
Songklanagarind Hospital ( Site 3501)

Hat Yai, Changwat Songkhla, 90110, Thailand
Southeastern Regional Medical Center ( Site 0010)

Newnan, Georgia, 30265, United States
St Bartholomews Hospital ( Site 1900)

London, London, City of, EC1A 7BE, United Kingdom
The Christie Hospital NHS Foundation Trust ( Site 1902)

Withington, Manchester, M20 4BX, United Kingdom
The Royal Cornwall Hospital ( Site 1904)

Truro, England, TR1 3LJ, United Kingdom
USC Norris Oncology Hematology Newport Beach ( Site 0029)

Newport Beach, California, 92663, United States
USC/Norris Comprehensive Cancer Center ( Site 0013)

Los Angeles, California, 90033, United States

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