New hope for advanced breast cancer: drug combo targets tumors after hormone therapy fails
NCT ID NCT06428396
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding belzutifan to fulvestrant can slow or stop the growth of a certain type of advanced breast cancer (ER+/HER2-) that has worsened despite hormone therapy. About 120 adults with inoperable or metastatic disease will receive either the new combination or standard treatment. The goal is to see if the new approach delays cancer progression.
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.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Bradfordhill ( Site 4100)
Santiago, Region M. de Santiago, 8420383, Chile
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CHRISTUS Highland ( Site 0005)
Shreveport, Louisiana, 71105, United States
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Cedars Sinai Medical Center ( Site 0012)
Beverly Hills, California, 90211, United States
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Centro de Investigaciones Metabólicas (CINME)-Oncology ( Site 0504)
CABA, Buenos Aires, C1056ABI, Argentina
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Centro de Investigación del Maule ( Site 4106)
Talca, Maule Region, 3460000, Chile
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City of Hope - Phoenix ( Site 0006)
Goodyear, Arizona, 85338, United States
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FALP ( Site 4102)
Santiago, Region M. de Santiago, 7500921, Chile
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Faculty of Medicine - Khon Kaen University ( Site 3502)
Muang, Changwat Khon Kaen, 40002, Thailand
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Faculty of Medicine Siriraj Hospital ( Site 3500)
Bangkoknoi, Bangkok, 10700, Thailand
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Fundacion Valle del Lili ( Site 1204)
Cali, Valle del Cauca Department, 760032, Colombia
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Hospital Británico de Buenos Aires-Oncology ( Site 0500)
Ciudad Autónoma de Buenos Aires, Buenos Aires, C1280AEB, Argentina
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Hospital Italiano de Córdoba ( Site 0508)
Córdoba, X5004BAL, Argentina
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IMAT S.A.S ( Site 1205)
Montería, Departamento de Córdoba, 230002, Colombia
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Instituto Alexander Fleming-Alexander Fleming ( Site 0505)
Buenos Aires, Buenos Aires F.D., C1426ANZ, Argentina
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Instituto de Investigaciones Clínicas Mar del Plata ( Site 0502)
Mar del Plata, Buenos Aires, B7600FZO, Argentina
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Instituto de Oncología de Rosario ( Site 0501)
Rosario, Santa Fe Province, S2000KZE, Argentina
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Ipswich Hospital ( Site 1911)
Ipswich, Suffolk, IP4 5PD, United Kingdom
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Jewish General Hospital ( Site 0400)
Montreal, Quebec, H3T 1E2, Canada
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MD Anderson ( Site 0015)
Houston, Texas, 77030, United States
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MD Anderson Cancer Center at Cooper ( Site 0024)
Camden, New Jersey, 08103, United States
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Mays Cancer Center ( Site 0022)
San Antonio, Texas, 78229, United States
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Medical College of Wisconsin - Froedtert Hospital ( Site 0014)
Milwaukee, Wisconsin, 53226, United States
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Moores Cancer Center at UC San Diego Health ( Site 0025)
La Jolla, California, 92093, United States
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National Cheng Kung University Hospital ( Site 3300)
Tainan, 704302, Taiwan
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National Taiwan University Cancer Center ( Site 3302)
Taipei, 106, Taiwan
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National Taiwan University Hospital ( Site 3301)
Taipei, 10002, Taiwan
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Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 0011)
Marietta, Georgia, 30060, United States
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Oncologos Del Occidente ( Site 1200)
Pereira, Risaralda Department, 660001, Colombia
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Pontificia Universidad Catolica de Chile ( Site 4108)
Santiago, Region M. de Santiago, 8330024, Chile
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Renown Regional Medical Center ( Site 0018)
Reno, Nevada, 89502, United States
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SSM Health Dean Medical Group - South Madison Campus Health Research/Circuit Clinical ( Site 0034)
Madison, Wisconsin, 53715, United States
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Samsung Medical Center ( Site 3101)
Seoul, 06351, South Korea
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Sanatorio Allende - Cerro-Oncology ( Site 0506)
Córdoba, Córdoba Province, 5000, Argentina
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Seoul National University Hospital ( Site 3100)
Seoul, 03080, South Korea
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Songklanagarind Hospital ( Site 3501)
Hat Yai, Changwat Songkhla, 90110, Thailand
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Southeastern Regional Medical Center ( Site 0010)
Newnan, Georgia, 30265, United States
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St Bartholomews Hospital ( Site 1900)
London, London, City of, EC1A 7BE, United Kingdom
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The Christie Hospital NHS Foundation Trust ( Site 1902)
Withington, Manchester, M20 4BX, United Kingdom
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The Royal Cornwall Hospital ( Site 1904)
Truro, England, TR1 3LJ, United Kingdom
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USC Norris Oncology Hematology Newport Beach ( Site 0029)
Newport Beach, California, 92663, United States
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USC/Norris Comprehensive Cancer Center ( Site 0013)
Los Angeles, California, 90033, United States