New hope for myeloma: targeted drug combo shows promise in Late-Stage trial

NCT ID NCT04484623

Ongoing Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 study tests whether adding the targeted drug belantamab mafodotin to standard medications (pomalidomide and dexamethasone) works better than another standard combo for people with multiple myeloma that has come back or stopped responding to treatment. About 302 participants will be randomly assigned to one of the two treatment groups. The main goal is to see how long the cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

belantamab mafodotin, pomalidomide, dexamethasone, bortezomib

What this could lead to

If successful, this combination could offer a more effective treatment option for people with multiple myeloma that has returned or stopped responding to prior therapy.

What could go wrong

This is an advanced phase 3 trial, but the new drug may not prove better than the standard combo, and side effects like eye problems or low blood counts are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Show contact details

Locations

GSK Investigational Site

Tucson, Arizona, 85712, United States
GSK Investigational Site

Fort Myers, Florida, 33901, United States
GSK Investigational Site

Boston, Massachusetts, 02215, United States
GSK Investigational Site

Kansas City, Missouri, 64132, United States
GSK Investigational Site

Nashville, Tennessee, 37203, United States
GSK Investigational Site

Garran, Australian Capital Territory, 2605, Australia
GSK Investigational Site

Darlinghurst, New South Wales, 2010, Australia
GSK Investigational Site

Gosford NSW, New South Wales, 2250, Australia
GSK Investigational Site

Port Macquarie, New South Wales, 2444, Australia
GSK Investigational Site

Benowa, Queensland, 4217, Australia
GSK Investigational Site

South Brisbane, Queensland, 4101, Australia
GSK Investigational Site

Adelaide, South Australia, 5000, Australia
GSK Investigational Site

Fitzroy, Victoria, 3065, Australia
GSK Investigational Site

Heidelberg, Victoria, 3084, Australia
GSK Investigational Site

Malvern, Victoria, 3144, Australia
GSK Investigational Site

Nedlands, Western Australia, 6009, Australia
GSK Investigational Site

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
GSK Investigational Site

Curitiba, 01308-050, Brazil
GSK Investigational Site

Joinville, 89201-260, Brazil
GSK Investigational Site

São Paulo, 04537-081, Brazil
GSK Investigational Site

Beijing, 100191, China
GSK Investigational Site

Beijing, China
GSK Investigational Site

Changchun, 130012, China
GSK Investigational Site

Changsha, 410013, China
GSK Investigational Site

Guangzhou, 510060, China
GSK Investigational Site

Hangzhou, 310003, China
GSK Investigational Site

Jiangsu, 221004, China
GSK Investigational Site

Nanchang, 330006, China
GSK Investigational Site

Shenyang, 110004, China
GSK Investigational Site

Shenzhen, 518029, China
GSK Investigational Site

Tianjin, 300020, China
GSK Investigational Site

Wuhan, 430022, China
GSK Investigational Site

Brno, 62500, Czechia
GSK Investigational Site

Hradec Králové, 50333, Czechia
GSK Investigational Site

Prague, 12808, Czechia
GSK Investigational Site

Marseille, 13273, France
GSK Investigational Site

Toulouse, 31059, France
GSK Investigational Site

Vanduvre-lEs-Nancy, 54511, France
GSK Investigational Site

Mainz, 55131, Germany
GSK Investigational Site

Tübingen, 72076, Germany
GSK Investigational Site

Würzburg, 97080, Germany
GSK Investigational Site

Athens, 10676, Greece
GSK Investigational Site

Athens, 115 25, Greece
GSK Investigational Site

Athens, 115 28, Greece
GSK Investigational Site

Ioannina, 45 500, Greece
GSK Investigational Site

Thessaloniki, 57010, Greece
GSK Investigational Site

Haifa, 3109601, Israel
GSK Investigational Site

Jerusalem, 91031, Israel
GSK Investigational Site

Kfar Saba, 4428164, Israel
GSK Investigational Site

Nahariya, 2633737, Israel
GSK Investigational Site

Petah Tikva, 4941492, Israel
GSK Investigational Site

Tel Aviv, 6423906, Israel
GSK Investigational Site

Bologna, 40138, Italy
GSK Investigational Site

Milan, 20122, Italy
GSK Investigational Site

Pavia, 27100, Italy
GSK Investigational Site

Roma, 00161, Italy
GSK Investigational Site

Aichi, 467-8602, Japan
GSK Investigational Site

Chiba, 277-8567, Japan
GSK Investigational Site

Chiba, 296-8602, Japan
GSK Investigational Site

Ehime, 790-8524, Japan
GSK Investigational Site

Fukushima, 960-1295, Japan
GSK Investigational Site

Gunma, 371-8511, Japan
GSK Investigational Site

Gunma, 377-0280, Japan
GSK Investigational Site

Hokkaido, 060-8648, Japan
GSK Investigational Site

Numakunai, 028-3695, Japan
GSK Investigational Site

Okayama, 701-1192, Japan
GSK Investigational Site

Osaka, 565-0871, Japan
GSK Investigational Site

Tottori, 683-8504, Japan
GSK Investigational Site

Yamagata, 990-9585, Japan
GSK Investigational Site

Auckland, 1023, New Zealand
GSK Investigational Site

Auckland, 2025, New Zealand
GSK Investigational Site

Dunedin, 9016, New Zealand
GSK Investigational Site

Hamilton, 3204, New Zealand
GSK Investigational Site

Takapuna Auckland, 622, New Zealand
GSK Investigational Site

Tauranga, 3143, New Zealand
GSK Investigational Site

Bydgoszcz, 85-168, Poland
GSK Investigational Site

Gdansk, 80-214, Poland
GSK Investigational Site

Krakow, 31-501, Poland
GSK Investigational Site

Lodz, 93-513, Poland
GSK Investigational Site

Wroclaw, 50-367, Poland
GSK Investigational Site

Moscow, 125101, Russia
GSK Investigational Site

Moscow, 125284, Russia
GSK Investigational Site

Novosibirsk, 630087, Russia
GSK Investigational Site

Saint Petersburg, 191024, Russia
GSK Investigational Site

Saint Petersburg, 194291, Russia
GSK Investigational Site

Saint Petersburg, 197341, Russia
GSK Investigational Site

Samara, 443099, Russia
GSK Investigational Site

Sochi, 354057, Russia
GSK Investigational Site

Gyeonggi-do, 10408, South Korea
GSK Investigational Site

Hwasun, 58128, South Korea
GSK Investigational Site

Inchon, 21565, South Korea
GSK Investigational Site

Seoul, 03080, South Korea
GSK Investigational Site

Seoul, 03722, South Korea
GSK Investigational Site

Seoul, 06351, South Korea
GSK Investigational Site

Seoul, 06591, South Korea
GSK Investigational Site

Barcelona, 08036, Spain
GSK Investigational Site

Barcelona, 8035, Spain
GSK Investigational Site

Gijón, 33204, Spain
GSK Investigational Site

L'Hospitalet de Llobrega, 08908, Spain
GSK Investigational Site

Madrid, 28006, Spain
GSK Investigational Site

Madrid, 28027, Spain
GSK Investigational Site

MOstoles Madrid, 28933, Spain
GSK Investigational Site

Murcia, 30008, Spain
GSK Investigational Site

Palma de Mallorca, 07120, Spain
GSK Investigational Site

PamplonaNavarra, 31008, Spain
GSK Investigational Site

Pozuelo de AlarcOn Madr, 28223, Spain
GSK Investigational Site

Salamanca, 37007, Spain
GSK Investigational Site

Seville, 41013, Spain
GSK Investigational Site

Valencia, 46026, Spain
GSK Investigational Site

Ankara, 06100, Turkey (Türkiye)
GSK Investigational Site

Ankara, 6340, Turkey (Türkiye)
GSK Investigational Site

Ankara, 6560, Turkey (Türkiye)
GSK Investigational Site

Izmir, 35100, Turkey (Türkiye)
GSK Investigational Site

Izmir, 35330, Turkey (Türkiye)
GSK Investigational Site

Kocaeli, 41400, Turkey (Türkiye)
GSK Investigational Site

Mersin, 33343, Turkey (Türkiye)
GSK Investigational Site

Samsun, 55139, Turkey (Türkiye)
GSK Investigational Site

London, W12 0HS, United Kingdom
GSK Investigational Site

Plymouth, PL6 8D8, United Kingdom
GSK Investigational Site

Southampton, SO16 6YD, United Kingdom
GSK Investigational Site

Stoke-on-Trent, ST4 6QG, United Kingdom
GSK Investigational Site

Sutton, SM2 5PT, United Kingdom