Light therapy may unlock immune secrets of common skin cancer
NCT ID NCT05020912
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how a light-based treatment called photodynamic therapy (PDT) changes the immune response in basal cell carcinoma (BCC), a common skin cancer. Researchers will treat one BCC lesion with PDT and then compare immune markers in treated and untreated tumors from 18 adults scheduled for surgery. The goal is to understand the immune changes better, which could help develop more effective combination therapies in the future.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Aminolevulinic acid (ALA) and blue light photodynamic therapy (PDT)
What this could lead to
If successful, this could point toward better combination treatments for basal cell carcinoma by understanding how PDT boosts the immune system.
What could go wrong
This is a very small, early-phase study (18 participants) focused on immune markers, not on curing cancer. The results may not lead to new treatments or apply to all patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cleveland Clinic, Case Comprehensive Cancer Center
Cleveland, Ohio, 44195, United States