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Engineered immune cells aim to stop bone Cancer's return in kids

NCT ID NCT07428993

Recruiting now Disease control Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase II trial tests whether a single infusion of B7-H3 CAR T cells, given after standard chemotherapy, can prevent the return of high-risk osteosarcoma in children. The study will enroll 41 participants who have completed upfront chemotherapy. Researchers will monitor how long participants stay cancer-free and track any side effects from the cell therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
B7-H3 CAR T cells (a type of immune cell therapy)
What this could lead to
If successful, this could offer a new way to prevent osteosarcoma from coming back after standard chemotherapy, potentially improving long-term survival for children with this aggressive cancer.
What could go wrong
This is a small, early-phase trial (41 participants) testing a complex cell therapy. It may not work for everyone, and there are risks of serious side effects like cytokine release syndrome or neurological problems. The long-term benefits are still unknown.

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Conditions

The condition(s) this trial relates to.

localized osteosarcoma osteosarcoma pediatric osteosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PEDIATRIC OSTEOSARCOMA

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • St. Jude Children's Research Hospital

    RECRUITING

    Memphis, Tennessee, 38105-2794, United States

    Contact Email: •••••@•••••

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