New drug targets genetic weakness in Hard-to-Treat cancers

NCT ID NCT04439123

First seen Nov 18, 2025 · Last updated Jun 15, 2026 · Updated 24 times

Summary

This study tests a drug called AZD5363 in 35 adults whose cancers have a specific genetic change (AKT mutation). The drug blocks a protein that helps cancer cells grow. Researchers want to see if it can shrink tumors or stop them from growing. Participants have advanced solid tumors, lymphoma, or multiple myeloma that haven't responded to other treatments.

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Contacts and locations

Locations

  • ECOG-ACRIN Cancer Research Group

    Philadelphia, Pennsylvania, 19103, United States

Conditions

Explore the condition pages connected to this study.