New drug aims to reverse wasting in cancer patients
NCT ID NCT05865535
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests AV-380, an antibody that blocks a protein linked to cancer-related weight loss (cachexia). About 30 adults with advanced solid tumors and high GDF-15 levels will receive AV-380 alongside their standard chemotherapy. The main goal is to check safety and find the right dose.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Advent Health Orlando Hospital
RECRUITINGOrlando, Florida, 32804, United States
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Astera Cancer Care
RECRUITINGEast Brunswick, New Jersey, 08816, United States
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Beverly Hills Cancer Center
RECRUITINGBeverly Hills, California, 90211, United States
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Cancer and Blood Specialty Clinic
RECRUITINGLakewood, California, 90712, United States
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Community Clinical Trials
RECRUITINGKingwood, Texas, 77339, United States
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Hartford Hospital
RECRUITINGHartford, Connecticut, 06102, United States
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Hoag Memorial Hospital
RECRUITINGNewport Beach, California, 92663, United States
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MUSC Hollings Cancer Center
RECRUITINGCharleston, South Carolina, 29425, United States
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Nebraska Cancer Specialists
RECRUITINGOmaha, Nebraska, 68130, United States
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New York Cancer And Blood Specialists
RECRUITINGShirley, New York, 11967, United States
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Oregon Health and Science University
RECRUITINGPortland, Oregon, 97239, United States
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Vanderbilt University Henry-Joyce Cancer Clinic
RECRUITINGNashville, Tennessee, 37232, United States