New knee implant system tested for Second-Time replacement patients

NCT ID NCT03153475

Ongoing Disease control Sponsor: DePuy Orthopaedics Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 07, 2026 · Updated 3 times

Summary

This study is testing the ATTUNE Revision Knee System in 400 people who need a second knee replacement (revision surgery). The goal is to see how well the implant holds up over 5 years and how it affects patients' pain, function, and quality of life. Participants will be followed for 5 years after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ATTUNE Revision Knee System (a device used in revision knee replacement surgery)
What this could lead to: If successful, this could show that the ATTUNE Revision Knee System is a safe and effective option for people needing a second knee replacement, helping improve function and quality of life.
What could go wrong: This is an early-stage, non-randomized study with no comparison group, so results may not apply to everyone. The device may fail or cause complications, and long-term benefits are not yet proven.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

REVISION TOTAL KNEE ARTHROPLASTY

Contacts and locations

Locations

Arthroplasty Foundation

Louisville, Kentucky, 40215, United States
Asklepios Orthopädische Klinik Lindenlohe

Schwandorf in Bayern, Germany
CHRU La Cavale Blanche

Brest, France
CLINICHE GAVAZZENI SPA aka Humanitas Castelli

Bergamo, Italy
Centre Hospitalier Universitaire de Rennes

Rennes, France
Chapel Allerton Orthopaedic Centre

Leeds, United Kingdom
Colorado Joint Replacement

Denver, Colorado, 80210, United States
Concordia Joint Replacement

Winnipeg, Canada
Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Florida Orthopedic Associates

DeLand, Florida, 32720, United States
Fondren Orthopedic Group

Houston, Texas, 77030, United States
Hampshire Hospitals NHS Foundation Trust

Basingstoke, United Kingdom
James Cook University Hospital

North Yorks, United Kingdom
Kantonsspital Baselland (Bruderholz, Liestal, Laufen), Department of Orthopaedic Surgery and Traumatology

Basel, Switzerland
Klinik und Poliklinik für Orthopädie und Sportorthopädie am Klinikum rechts der Isar der Technischen Universität Münche

Munich, Germany
Krankenhaus der Barmherzigen Schwestern Linz Betriebsgesellschaft m.b.H.

Linz, Austria
London Health Sciences Centre University Hospital

London, Ontario, Canada
Mery Hospital

Ozark, Missouri, 65721, United States
MoRe Foundation

Antwerp, Belgium
Nuffield Orthopaedic Centre

Oxford, United Kingdom
OrthoCarolina Hip and Knee Center

Charlotte, North Carolina, 28207, United States
Orthopaedic Center of the Rockies

Fort Collins, Colorado, 80525, United States
Orthopedic Partners

Niantic, Connecticut, 06357, United States
Rothman Institute

Egg Harbor, New Jersey, 08234, United States
Scripps Clinic Torrey Pines

San Diego, California, 92037, United States
South Infirmary Public Hospital

Cork, Ireland
Southern Joint Replacement Institute

Nashville, Tennessee, 37203, United States
St. John of God Murdoch Hospital

Perth, Australia
Texas Institute for Hip & Knee Surgery

Austin, Texas, 78751, United States
The Gold Coast Centre for Bone and Joint Surgery

Gold Coast, Australia
The Ohio State University Wexner Medical Center

Columbus, Ohio, 43210, United States
The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust

Oswestry, United Kingdom
UNC Orthopaedics

Chapel Hill, North Carolina, 27514, United States
University Hospital Maastricht

Maastricht, Netherlands
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
Victoria Hospital NHS Fife

Kirkcaldy, United Kingdom
Wellington Hospital

Wellington, New Zealand
Wrightington Hospital

Wigan, United Kingdom

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