New knee implant system tested for Second-Time replacement patients
NCT ID NCT03153475
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing the ATTUNE Revision Knee System in 400 people who need a second knee replacement (revision surgery). The goal is to see how well the implant holds up over 5 years and how it affects patients' pain, function, and quality of life. Participants will be followed for 5 years after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ATTUNE Revision Knee System (a device used in revision knee replacement surgery)
What this could lead to
If successful, this could show that the ATTUNE Revision Knee System is a safe and effective option for people needing a second knee replacement, helping improve function and quality of life.
What could go wrong
This is an early-stage, non-randomized study with no comparison group, so results may not apply to everyone. The device may fail or cause complications, and long-term benefits are not yet proven.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Arthroplasty Foundation
Louisville, Kentucky, 40215, United States
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Asklepios Orthopädische Klinik Lindenlohe
Schwandorf in Bayern, Germany
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CHRU La Cavale Blanche
Brest, France
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CLINICHE GAVAZZENI SPA aka Humanitas Castelli
Bergamo, Italy
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Centre Hospitalier Universitaire de Rennes
Rennes, France
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Chapel Allerton Orthopaedic Centre
Leeds, United Kingdom
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Colorado Joint Replacement
Denver, Colorado, 80210, United States
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Concordia Joint Replacement
Winnipeg, Canada
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Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, 03756, United States
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Florida Orthopedic Associates
DeLand, Florida, 32720, United States
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Fondren Orthopedic Group
Houston, Texas, 77030, United States
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Hampshire Hospitals NHS Foundation Trust
Basingstoke, United Kingdom
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James Cook University Hospital
North Yorks, United Kingdom
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Kantonsspital Baselland (Bruderholz, Liestal, Laufen), Department of Orthopaedic Surgery and Traumatology
Basel, Switzerland
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Klinik und Poliklinik für Orthopädie und Sportorthopädie am Klinikum rechts der Isar der Technischen Universität Münche
Munich, Germany
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Krankenhaus der Barmherzigen Schwestern Linz Betriebsgesellschaft m.b.H.
Linz, Austria
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London Health Sciences Centre University Hospital
London, Ontario, Canada
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Mery Hospital
Ozark, Missouri, 65721, United States
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MoRe Foundation
Antwerp, Belgium
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Nuffield Orthopaedic Centre
Oxford, United Kingdom
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OrthoCarolina Hip and Knee Center
Charlotte, North Carolina, 28207, United States
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Orthopaedic Center of the Rockies
Fort Collins, Colorado, 80525, United States
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Orthopedic Partners
Niantic, Connecticut, 06357, United States
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Rothman Institute
Egg Harbor, New Jersey, 08234, United States
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Scripps Clinic Torrey Pines
San Diego, California, 92037, United States
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South Infirmary Public Hospital
Cork, Ireland
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Southern Joint Replacement Institute
Nashville, Tennessee, 37203, United States
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St. John of God Murdoch Hospital
Perth, Australia
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Texas Institute for Hip & Knee Surgery
Austin, Texas, 78751, United States
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The Gold Coast Centre for Bone and Joint Surgery
Gold Coast, Australia
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The Ohio State University Wexner Medical Center
Columbus, Ohio, 43210, United States
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The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust
Oswestry, United Kingdom
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UNC Orthopaedics
Chapel Hill, North Carolina, 27514, United States
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University Hospital Maastricht
Maastricht, Netherlands
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University of Mississippi Medical Center
Jackson, Mississippi, 39216, United States
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Victoria Hospital NHS Fife
Kirkcaldy, United Kingdom
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Wellington Hospital
Wellington, New Zealand
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Wrightington Hospital
Wigan, United Kingdom