Bone injection may boost antibiotic power in knee surgery
NCT ID NCT07283068
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving the antibiotic vancomycin directly into the bone (via the ankle) works better than the usual IV method during revision knee replacement surgery. Forty adults having a second knee replacement will be randomly assigned to one of the two methods. Researchers will measure antibiotic levels in the bone and blood to see which route provides higher concentrations where it matters most.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- vancomycin
- What this could lead to
- If this works, it could show that injecting antibiotics directly into the bone is better at preventing infection during knee replacement surgery.
- What could go wrong
- This is a very small, early study with only 40 people. It measures antibiotic levels, not actual infection rates, so it may not lead to better outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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