Knee surgery antibiotic showdown: injection into bone vs vein

NCT ID NCT07283068

First seen Jan 10, 2026 · Last updated May 14, 2026 · Updated 20 times

Summary

This study looks at two methods of giving the antibiotic vancomycin during revision knee replacement surgery: injecting it into a vein (IV) or directly into the ankle bone (intraosseous). The goal is to see which method delivers higher antibiotic levels to the knee area to better prevent infection. About 40 adults having revision knee surgery will take part. This is an early-stage comparison, not a treatment study.

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