Closed-Loop stimulation combined with left bundle branch area pacing in patients with atrioventricular conduction disorders
NCT ID NCT07812935
First seen Sep 10, 2026 · Last updated Sep 10, 2026
Summary
This prospective, single-center, crossover study evaluated the effects of closed-loop stimulation (CLS) compared with conventional accelerometer-based rate-adaptive pacing (VVIR) in patients with permanent atrial fibrillation undergoing left bundle branch area pacing (LBBAP). Chronotropic responses were evaluated during standardized mental and physical stress testing. Heart rate distribution during daily activity, functional capacity, quality of life, and device-related parameters were also assessed.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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33 people
The number who actually took part.
- Started
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Jun 2025
- Finished
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Jul 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥18 years * Permanent atrial fibrillation * Chronotropic incompetence * Permanent pacemaker with left bundle branch area pacing (LBBAP) * Ventricular pacing burden \>50% * Ability to provide written informed consent Exclusion Criteria: * Age \<18 years * Inability or unwillingness to provide informed consent
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Clinical Provincial Hospital No. 2 in Rzeszow
Rzeszów, Podkarpackie Voivodeship, 35-302, Poland
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Development and evaluation of the effectiveness of a mobile individual atrial fibrillation management (m-BAFY) program
- A prospective, multicenter, randomized controlled, non-inferiority clinical trial evaluating the safety and efficacy of cardiac pulsed field ablation devices combined with single-use spherical pulsed ablation catheters in treating paroxysmal atrial fibrillation
- Evaluation of the factors associated with bradtycardia following pulmonary vein isolation using pulsed field ablation
- Can remote exercise sessions boost heart recovery after ablation?
- Can a heart drug keep atrial fibrillation at bay after ablation?
- Can a new drug stop long atrial fibrillation episodes?