Immunotherapy joins forces with standard drugs in breast cancer trial
NCT ID NCT03125928
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether adding the immunotherapy drug atezolizumab to a standard combination of chemotherapy (paclitaxel) and two targeted drugs (trastuzumab and pertuzumab) is safe and effective for people with advanced HER2-positive breast cancer that has spread. The study includes 16 participants and aims to reduce the use of steroids that might interfere with the immune response. Researchers are tracking side effects and tumor shrinkage.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Atezolizumab (immunotherapy) plus paclitaxel (chemotherapy), trastuzumab, and pertuzumab (targeted therapies)
What this could lead to
If it works, this could improve treatment options for people with advanced HER2-positive breast cancer by adding an immunotherapy drug to the standard regimen.
What could go wrong
This is a small, early-phase trial with only 16 participants, so results may not apply widely. Adding immunotherapy can also increase side effects like immune-related inflammation.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States