New pill could cool menopause hot flashes without hormones

NCT ID NCT07042516

Recruiting now Symptom relief Sponsor: Tioga Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 2 times

Summary

This study tests a drug called asimadoline (TP0052) for moderate to severe hot flashes and night sweats in women aged 40-62. About 120 women will take either the drug or a placebo for 8 weeks, then all will get the drug for 4 more weeks. The goal is to see if it safely reduces the number of hot flashes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: asimadoline (TP0052)
What this could lead to: If it works, this could offer a new non-hormonal option to reduce hot flashes and night sweats in menopausal women.
What could go wrong: This is an early Phase 2 trial with only 120 people, so results may not apply widely. The drug may not work better than placebo or could cause side effects like nausea or dizziness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hot Flashes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VASOMOTOR SYMPTOMS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Department of Gynecology & Obstetrics, Emory University School of Medicine
RECRUITING

Atlanta, Georgia, 30329, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

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