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A plant compound may help young teeth heal themselves

NCT ID NCT07802340

Disease control Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 03, 2026 · Last updated Sep 16, 2026 · Updated 3 times

Summary

This trial tests whether a plant-derived compound called asiaticoside, placed inside the tooth, can improve the revascularization process in immature permanent teeth with dead nerves. Researchers will compare asiaticoside to the standard calcium hydroxide medication. The goal is to see if asiaticoside leads to greater root growth, thicker dentin walls, and better bone healing around the tooth root.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
asiaticoside
What this could lead to
If asiaticoside works, it could offer a better way to help immature permanent teeth with dead nerves regrow roots and heal, potentially saving teeth that might otherwise be lost.
What could go wrong
This is a small early-stage trial with only 20 participants, so results may not apply broadly. Asiaticoside's effectiveness and safety as a dental medication are not yet established.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

8 to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Both gender * patients having permanent anterior teeth with necrotic pulp and immature apex * Good general health * pulp space not needed for post and core Exclusion Criteria: * Radiographic identification of root fracture or abnormality * Uncooperative patients * Root resorption (internal or external)

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Conditions

The condition(s) this trial relates to.

dental pulp necrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Revascularization of immature young permanent teeth with pulp necrosis Revascularization of immature young permenant teeth

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Mansoura University

    RECRUITING

    Al Mansurah, Egypt

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